FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567407995> ?p ?o ?g. }

• W1567407995 endingPage "731" @default.
• W1567407995 startingPage "719" @default.
• W1567407995 abstract "Dichloroacetic acid (DCA) is commonly found in drinking water as a by-product of chlorination disinfection. It is a known neurotoxicant in rats, dogs, and humans. We have characterized DCA neurotoxicity in rats using a neurobehavioral screening battery under varying exposure durations (acute, subchronic, and chronic) and routes of administration (oral gavage and drinking water). Studies were conducted in both weanling and adult rats, and comparisons were made between Long-Evans and Fischer-344 rats. DCA produced neuromuscular toxicity comprised of limb weakness and deficits in gait and righting reflex; altered gait and decreased hindlimb grip strength were the earliest indicators of toxicity. Other effects included mild tremors, ocular abnormalities, and a unique chest-clasping response (seen in Fischer-344 rats only). Neurotoxicity was permanent (i.e., through 2 years) following a 6-month exposure to high dose levels, whereas the effects of intermediate dose levels with exposures of 3 months or less were slowly reversible. The severity, specificity, and recovery of neurological changes were route, duration, and strain dependent. Fischer-344 rats were more sensitive than Long-Evans rats, and weanling rats may be somewhat more sensitive than adults. Oral gavage produced significantly less toxicity compared to the same intake level received in drinking water. Neurotoxicity was progressive with continued exposure, and was observed at exposure levels as low as 16 mg/kg/day (lowest dose level tested) when administered via drinking water in subchronic studies. The data from these studies characterize the neurotoxicity produced by DCA, and show it to be more pronounced, persistent, and occurring at lower exposures than has been previously reported. Further research should take into account these marked route, age, and strain differences." @default.
• W1567407995 created "2016-06-24" @default.
• W1567407995 creator A5027072959 @default.
• W1567407995 creator A5042207958 @default.
• W1567407995 creator A5057753493 @default.
• W1567407995 creator A5065793115 @default.
• W1567407995 date "1999-11-01" @default.
• W1567407995 modified "2023-09-23" @default.
• W1567407995 title "Behavioral Evaluation of the Neurotoxicity Produced by Dichloroacetic Acid in Rats11Portions of this research were presented at the annual Society of Toxicology meeting (The Toxiologist 13:252; 1993) and at the ILSI Workshop on Disinfection By-Products, 1995." @default.
• W1567407995 cites W1485982079 @default.
• W1567407995 cites W1527076520 @default.
• W1567407995 cites W1580320138 @default.
• W1567407995 cites W1966602972 @default.
• W1567407995 cites W1987654201 @default.
• W1567407995 cites W1991635672 @default.
• W1567407995 cites W1994148625 @default.
• W1567407995 cites W1994269797 @default.
• W1567407995 cites W2002086621 @default.
• W1567407995 cites W2007015999 @default.
• W1567407995 cites W2010819439 @default.
• W1567407995 cites W2013529252 @default.
• W1567407995 cites W2014260144 @default.
• W1567407995 cites W2017106963 @default.
• W1567407995 cites W2029180580 @default.
• W1567407995 cites W2040117502 @default.
• W1567407995 cites W2042931612 @default.
• W1567407995 cites W2052160437 @default.
• W1567407995 cites W2052390369 @default.
• W1567407995 cites W2054504713 @default.
• W1567407995 cites W2059847110 @default.
• W1567407995 cites W2060936796 @default.
• W1567407995 cites W2066033305 @default.
• W1567407995 cites W2069205839 @default.
• W1567407995 cites W2075335648 @default.
• W1567407995 cites W2082100392 @default.
• W1567407995 cites W2092879394 @default.
• W1567407995 cites W2093327304 @default.
• W1567407995 cites W2123119198 @default.
• W1567407995 cites W2127173373 @default.
• W1567407995 cites W2131960564 @default.
• W1567407995 cites W2135372970 @default.
• W1567407995 cites W2217366934 @default.
• W1567407995 cites W2404809361 @default.
• W1567407995 cites W2790855015 @default.
• W1567407995 doi "https://doi.org/10.1016/s0892-0362(99)00029-x" @default.
• W1567407995 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10560779" @default.
• W1567407995 hasPublicationYear "1999" @default.
• W1567407995 type Work @default.
• W1567407995 sameAs 1567407995 @default.
• W1567407995 citedByCount "35" @default.
• W1567407995 countsByYear W15674079952012 @default.
• W1567407995 countsByYear W15674079952014 @default.
• W1567407995 countsByYear W15674079952015 @default.
• W1567407995 countsByYear W15674079952017 @default.
• W1567407995 countsByYear W15674079952018 @default.
• W1567407995 countsByYear W15674079952019 @default.
• W1567407995 countsByYear W15674079952020 @default.
• W1567407995 countsByYear W15674079952021 @default.
• W1567407995 countsByYear W15674079952022 @default.
• W1567407995 countsByYear W15674079952023 @default.
• W1567407995 crossrefType "journal-article" @default.
• W1567407995 hasAuthorship W1567407995A5027072959 @default.
• W1567407995 hasAuthorship W1567407995A5042207958 @default.
• W1567407995 hasAuthorship W1567407995A5057753493 @default.
• W1567407995 hasAuthorship W1567407995A5065793115 @default.
• W1567407995 hasConcept C126322002 @default.
• W1567407995 hasConcept C185592680 @default.
• W1567407995 hasConcept C2777616060 @default.
• W1567407995 hasConcept C2778433245 @default.
• W1567407995 hasConcept C2779491297 @default.
• W1567407995 hasConcept C29730261 @default.
• W1567407995 hasConcept C33070731 @default.
• W1567407995 hasConcept C42219234 @default.
• W1567407995 hasConcept C42407357 @default.
• W1567407995 hasConcept C55493867 @default.
• W1567407995 hasConcept C71924100 @default.
• W1567407995 hasConcept C86803240 @default.
• W1567407995 hasConcept C98274493 @default.
• W1567407995 hasConceptScore W1567407995C126322002 @default.
• W1567407995 hasConceptScore W1567407995C185592680 @default.
• W1567407995 hasConceptScore W1567407995C2777616060 @default.
• W1567407995 hasConceptScore W1567407995C2778433245 @default.
• W1567407995 hasConceptScore W1567407995C2779491297 @default.
• W1567407995 hasConceptScore W1567407995C29730261 @default.
• W1567407995 hasConceptScore W1567407995C33070731 @default.
• W1567407995 hasConceptScore W1567407995C42219234 @default.
• W1567407995 hasConceptScore W1567407995C42407357 @default.
• W1567407995 hasConceptScore W1567407995C55493867 @default.
• W1567407995 hasConceptScore W1567407995C71924100 @default.
• W1567407995 hasConceptScore W1567407995C86803240 @default.
• W1567407995 hasConceptScore W1567407995C98274493 @default.
• W1567407995 hasIssue "6" @default.
• W1567407995 hasLocation W15674079951 @default.
• W1567407995 hasLocation W15674079952 @default.
• W1567407995 hasOpenAccess W1567407995 @default.
• W1567407995 hasPrimaryLocation W15674079951 @default.
• W1567407995 hasRelatedWork W1567407995 @default.
• W1567407995 hasRelatedWork W2053722599 @default.

• next