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• W1567427300 abstract "Pulmonary arterial hypertension (PAH) is a multi-factorial, progressive disease with substantial mortality and morbidity. Despite recent improvements in treatment, mortality associated with PAH remains high, with a two-year survival rate after diagnosis of approximately 85% (Thenappan et al., 2007). Although advances in the understanding of disease development and treatment have been achieved, the pathogenesis of PAH is still not clearly understood (Humbert et al., 2004). Therapeutic options remain limited despite the introduction of prostacyclin analogues, endothelin receptor antagonists and phosphodiesterase 5 inhibitors within the last 15 years. Moreover, these interventions predominantly address the endothelial and vascular dysfunction associated with the condition, and thus merely delay the progression of the disease rather than offer a cure (McLaughlin et al., 2009a, McLaughlin et al., 2009b)." @default.
• W1567427300 created "2016-06-24" @default.
• W1567427300 creator A5015738867 @default.
• W1567427300 creator A5063765011 @default.
• W1567427300 creator A5076787394 @default.
• W1567427300 creator A5081614754 @default.
• W1567427300 date "2011-12-09" @default.
• W1567427300 modified "2023-10-03" @default.
• W1567427300 title "&#969;3 and &#969;6 CYP450 Eicosanoid Derivatives: Key Lipid Mediators in the Regulation of Pulmonary Hypertension" @default.
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