FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567435240> ?p ?o ?g. }

• W1567435240 endingPage "1405" @default.
• W1567435240 startingPage "1393" @default.
• W1567435240 abstract "Tributyltin (TBT), a well-known endocrine disruptor, is an omnipresent environmental pollutant and is explicitly used in many industrial applications. Previously we have shown its neurotoxic potential on cerebral cortex of male Wistar rats. As the effect of TBT on other brain regions is not known, we planned this study to evaluate its effect on four brain regions (cerebellum, hippocampus, hypothalamus, and striatum). Four-week-old male Wistar rats were gavaged with a single dose of TBT-chloride (TBTC) (10, 20, and 30 mg/kg) and sacrificed on days 3 and 7, respectively. Effect of TBTC on blood-brain barrier (BBB) permeability and tin (Sn) accumulation were measured. Oxidative stress indexes such as reactive oxygen species (ROS), reduced and oxidized glutathione (GSH/GSSG) ratio, lipid peroxidation, and protein carbonylation were analyzed as they play an imperative role in various neuropathological conditions. Since metal catalyzed reactions are a major source of oxidant generation, levels of essential metals like iron (Fe), zinc (Zn), and calcium (Ca) were estimated. We found that TBTC disrupted BBB and increased Sn accumulation, both of which appear significantly correlated. Altered metal homeostasis and ROS generation accompanied by elevated lipid peroxidation and protein carbonylation indicated oxidative damage which appeared more pronounced in the striatum than in cerebellum, hippocampus, and hypothalamus. This could be associated to the depleted GSH levels in striatum. These results suggest that striatum is more susceptible to TBTC induced oxidative damage as compared with other brain regions under study." @default.
• W1567435240 created "2016-06-24" @default.
• W1567435240 creator A5011246605 @default.
• W1567435240 creator A5047577367 @default.
• W1567435240 creator A5051089241 @default.
• W1567435240 date "2014-06-03" @default.
• W1567435240 modified "2023-10-16" @default.
• W1567435240 title "Differential susceptibility of brain regions to tributyltin chloride toxicity" @default.
• W1567435240 cites W1538748480 @default.
• W1567435240 cites W1588570886 @default.
• W1567435240 cites W1971775352 @default.
• W1567435240 cites W1976364159 @default.
• W1567435240 cites W1979164709 @default.
• W1567435240 cites W1982425917 @default.
• W1567435240 cites W1983310681 @default.
• W1567435240 cites W1985015502 @default.
• W1567435240 cites W1991971544 @default.
• W1567435240 cites W1992377755 @default.
• W1567435240 cites W1993250284 @default.
• W1567435240 cites W1994956146 @default.
• W1567435240 cites W1996710971 @default.
• W1567435240 cites W1998743558 @default.
• W1567435240 cites W2002559713 @default.
• W1567435240 cites W2003815900 @default.
• W1567435240 cites W2007271603 @default.
• W1567435240 cites W2007649442 @default.
• W1567435240 cites W2017852034 @default.
• W1567435240 cites W2026261400 @default.
• W1567435240 cites W2036130849 @default.
• W1567435240 cites W2038655675 @default.
• W1567435240 cites W2041821288 @default.
• W1567435240 cites W2043865650 @default.
• W1567435240 cites W2044412397 @default.
• W1567435240 cites W2044692821 @default.
• W1567435240 cites W2062845561 @default.
• W1567435240 cites W2064962586 @default.
• W1567435240 cites W2068717435 @default.
• W1567435240 cites W2077610828 @default.
• W1567435240 cites W2081412929 @default.
• W1567435240 cites W2087141513 @default.
• W1567435240 cites W2087244055 @default.
• W1567435240 cites W2087607022 @default.
• W1567435240 cites W2094047820 @default.
• W1567435240 cites W2099343538 @default.
• W1567435240 cites W2124603205 @default.
• W1567435240 cites W2136099556 @default.
• W1567435240 cites W2140073946 @default.
• W1567435240 cites W2147869187 @default.
• W1567435240 cites W2149269973 @default.
• W1567435240 cites W2151723746 @default.
• W1567435240 cites W2153819462 @default.
• W1567435240 cites W2159071874 @default.
• W1567435240 cites W2164268814 @default.
• W1567435240 cites W2166447472 @default.
• W1567435240 cites W2166794793 @default.
• W1567435240 cites W4293247451 @default.
• W1567435240 cites W4317927708 @default.
• W1567435240 doi "https://doi.org/10.1002/tox.22009" @default.
• W1567435240 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24895210" @default.
• W1567435240 hasPublicationYear "2014" @default.
• W1567435240 type Work @default.
• W1567435240 sameAs 1567435240 @default.
• W1567435240 citedByCount "17" @default.
• W1567435240 countsByYear W15674352402015 @default.
• W1567435240 countsByYear W15674352402016 @default.
• W1567435240 countsByYear W15674352402017 @default.
• W1567435240 countsByYear W15674352402018 @default.
• W1567435240 countsByYear W15674352402019 @default.
• W1567435240 countsByYear W15674352402020 @default.
• W1567435240 countsByYear W15674352402021 @default.
• W1567435240 countsByYear W15674352402022 @default.
• W1567435240 crossrefType "journal-article" @default.
• W1567435240 hasAuthorship W1567435240A5011246605 @default.
• W1567435240 hasAuthorship W1567435240A5047577367 @default.
• W1567435240 hasAuthorship W1567435240A5051089241 @default.
• W1567435240 hasConcept C107872376 @default.
• W1567435240 hasConcept C126322002 @default.
• W1567435240 hasConcept C134018914 @default.
• W1567435240 hasConcept C178790620 @default.
• W1567435240 hasConcept C181199279 @default.
• W1567435240 hasConcept C185592680 @default.
• W1567435240 hasConcept C2776151105 @default.
• W1567435240 hasConcept C2779078112 @default.
• W1567435240 hasConcept C2779652256 @default.
• W1567435240 hasConcept C2780062018 @default.
• W1567435240 hasConcept C2780829032 @default.
• W1567435240 hasConcept C2911203004 @default.
• W1567435240 hasConcept C29730261 @default.
• W1567435240 hasConcept C48349386 @default.
• W1567435240 hasConcept C513476851 @default.
• W1567435240 hasConcept C538909803 @default.
• W1567435240 hasConcept C55493867 @default.
• W1567435240 hasConcept C71924100 @default.
• W1567435240 hasConcept C86803240 @default.
• W1567435240 hasConcept C98274493 @default.
• W1567435240 hasConceptScore W1567435240C107872376 @default.
• W1567435240 hasConceptScore W1567435240C126322002 @default.
• W1567435240 hasConceptScore W1567435240C134018914 @default.

• next