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- W1567449958 abstract "Abstract The in vitro mammalian cell mutation assays used for preclinical safety testing detect forward mutations at various target genes. The most frequently used in vitro cell mutation assay in drug development is the Mouse Lymphoma Assay (MLA). This article discusses various aspects of regulatory guidance for the use of in vitro mammalian cell mutation assays and their role in genetic toxicity evaluation of pharmaceuticals." @default.
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- W1567449958 date "2010-03-15" @default.
- W1567449958 modified "2023-09-26" @default.
- W1567449958 title "<i>In Vitro</i> Mammalian Cell Mutation Assays" @default.
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- W1567449958 doi "https://doi.org/10.1002/9780470571224.pse073" @default.
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