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- W1567451919 abstract "Dactinomycin has prolonged the survival of B/W female mice significantly, whether begun at 4 months of age, before renal manifestations were evident, or at 6–6.5 months after some mice had died and many had heavy proteinuria. In the present series of experiments, when treatment was further delayed until most of the surviving animals had heavy proteinuria, longevity was again significantly increased, with apparently improved renal function in some of the mice. Lower doses of the drug begun at 4 months were also effective. When the drug was begun at 4 months and discontinued at 12 months of age, most mice developed late severe renal disease but escaped the tumors found in mice whose treatment was continued." @default.
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- W1567451919 date "1980-10-01" @default.
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- W1567451919 title "Dactinomycin treatment of murine lupus erythematosus" @default.
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- W1567451919 doi "https://doi.org/10.1016/0090-1229(80)90094-x" @default.
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