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• W1567460162 abstract "For gastric cancer surgery is the mainstay treatment. Chemotherapy seems to improve the survival results. But chemotherapy is not a complication-free therapy and its role has been questioned by some trials.To determine whether post-surgical chemotherapy should be used routinely in resectable gastric cancer.We searched the Cochrane Central Register of Controlled Trials (CENTRAL) in The Cochrane Library, MEDLINE, EMBASE, and Science Citation Index Expanded (July 2013).Randomised controlled trials (RCT) comparing post-surgical chemotherapy versus surgery alone for resectable gastric cancer.Two authors independently assessed trials for inclusion and independently extracted the data. We analysed the data with both the fixed-effect and the random-effects models using the RevMan analysis software. We calculated the hazard ratio (HR) with 95% confidence interval (CI) based on intention-to-treat or available case analysis.The authors identified 34 studies (7824 patients) reporting overall survival (OS) and only 15 reporting disease free survival (DFS) as well. Post-surgical chemotherapy showed an improvement in OS (HR 0.85; 95% CI 0.80 to 0.90) and an improvement in DFS (HR 0.79; 95% CI 0.72 to 0.87), although all the trials had a high risk of bias.The planned analysis of quality of life, return to work, and number of hospital admissions was impossible to complete as the outcome data for the analysis were not available from any trials.Post-surgical chemotherapy should be used routinely for resectable gastric cancer where possible. Further RCTs are needed to determine the role at each stage of disease." @default.
• W1567460162 created "2016-06-24" @default.
• W1567460162 creator A5020868778 @default.
• W1567460162 creator A5027651047 @default.
• W1567460162 creator A5083954628 @default.
• W1567460162 date "2013-09-02" @default.
• W1567460162 modified "2023-10-18" @default.
• W1567460162 title "Post-surgical chemotherapy versus surgery alone for resectable gastric cancer" @default.
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• W1567460162 doi "https://doi.org/10.1002/14651858.cd008415.pub2" @default.
• W1567460162 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23999923" @default.
• W1567460162 hasPublicationYear "2013" @default.
• W1567460162 type Work @default.
• W1567460162 sameAs 1567460162 @default.

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