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• W1567464267 abstract "Aggregation of tau proteins followed by formation of paired helical filaments and neurofibrillary tangles is considered as a hallmark of certain neurodegenerative disorders such as different tauopathies and Alzheimer's disease (AD). Tau aggregation is dependent on the presence of polyanions, cellul ar redox state, limited proteolysis, and different posttranslational modifications among which tau phosphorylation plays a particularly important role. Although it is still debatable whether tau aggregation is harmful or protective for the cell, detailed analysis of molecular mechanisms underlying this process seems to be of great importance for understanding AD pathogenesis. This review is focused on universal adapter proteins 14-3-3 that seem to be significant partners to tau protein in neurons. 14-3-3 interacts with nonphosphorylated tau and promotes its interaction with and phosphorylation by a number of protein kinases. 14-3-3 induces aggregation of nonphosphorylated tau and does not affect aggregation of tau phosphorylated at specific sites. Due to its high concentration in neurons, 14-3-3 can compete with tubulin for interaction with tau. Binding to phosphorylated tau, 14-3-3 might inhibit its dephosphorylation by protein phosphatases and by this means indirectly affect interaction of tau with microtubules and tau aggregation. Finally, 14-3-3 might promote sequestration of dangerous small tau oligomers and stabilize tau aggregates. We propose that 14-3-3 should be considered an important participant of the complex process of tau aggregation and as a potential therapeutic target in treating AD." @default.
• W1567464267 created "2016-06-24" @default.
• W1567464267 creator A5035500096 @default.
• W1567464267 creator A5075390470 @default.
• W1567464267 date "2011-11-29" @default.
• W1567464267 modified "2023-10-16" @default.
• W1567464267 title "Probable Participation of 14-3-3 in Tau Protein Oligomerization and Aggregation" @default.
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• W1567464267 doi "https://doi.org/10.3233/jad-2011-110692" @default.
• W1567464267 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21876254" @default.
• W1567464267 hasPublicationYear "2011" @default.
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