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- W1567467654 abstract "This chapter discusses the various pathways through the vacuolar compartment. The essential route through the vacuolar compartment consists of three component activities: entry, transit and recycling. Entry that includes the processes of phagocytosis, pinocytosis and receptor-mediated endocytosis, occurs when plasma membrane invaginates to enclose extracellular molecules or particles into intracellular vesicles. Subsequent membrane fusion and fission reactions typically deliver the contents of these vesicles to endosomes and then to lysosomes, where most macromolecules are degraded by acid hydrolases. The exchange of membrane and content that occurs en route to lysosomes, and the mechanisms that reestablish compartment identities, allow some internalized membrane and solutes to recycle to the cell surface. The net effect is that extracellular solutes and particles are delivered efficiently to lysosomes through a series of compartments whose distinct identities are maintained even as the exogenous passengers move through them. The chapter also describes a model to explain pathways dynamics. The aim is to describe the general flow of membrane, solutes, water, and macromolecules into and through the macrophage." @default.
- W1567467654 created "2016-06-24" @default.
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- W1567467654 date "1999-01-01" @default.
- W1567467654 modified "2023-10-13" @default.
- W1567467654 title "Pathways through the macrophage vacuolar compartment" @default.
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- W1567467654 doi "https://doi.org/10.1016/s1874-5172(99)80035-2" @default.
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