Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567469571> ?p ?o ?g. }
- W1567469571 endingPage "7349" @default.
- W1567469571 startingPage "7341" @default.
- W1567469571 abstract "Abstract The recruitment of leukocytes to injured tissue is crucial for the initiation of inflammatory responses as well as for immune surveillance to fight tumor progression. In this study, we show that oncostatin M, a member of the IL-6-type cytokine family and potent proinflammatory cytokine stimulates the expression of the chemokines CCL1, CCL7, and CCL8 in primary human dermal fibroblasts at a faster kinetic than IL-1β or TNF-α. The production of CCL1 and CCL8 is important for migration of monocytes, while specific Abs against CCL1 additionally inhibit the migration of T lymphocytes. We identify the mitogen-activated protein kinases ERK1/2 and p38 as crucial factors for the enhanced expression of CCL1 and CCL8. Depletion of the ERK1/2 target genes c-Jun or c-Fos strongly decrease CCL1 and CCL8 expression, while p38 MAPK prolongs the half-life of CCL1, CCL7, and CCL8 mRNA through inhibition of tristetraprolin. None of the STAT transcription factors STAT1, STAT3, or STAT5 stimulate transcription of CCL1 or CCL8. However, we identify a negative regulatory function of activated STAT5 for the gene expression of CCL1. Importantly, not STAT5 itself, but its target gene cytokine inducible SH2-domain containing protein is required for the STAT5 inhibitory effect on CCL1 expression. Finally, we show that constitutive activation of STAT5 through a mutated form of JAK2 (JAK2 V617F) occurring in patients with myeloproliferative disorders similarly suppresses CCL1 expression. Taken together, we identify novel important inflammatory target genes of OSM which are independent of STAT signaling per se, but depend on MAPK activation and are partly repressed through STAT5-dependent expression of cytokine inducible SH2-domain containing protein." @default.
- W1567469571 created "2016-06-24" @default.
- W1567469571 creator A5003694440 @default.
- W1567469571 creator A5008200603 @default.
- W1567469571 creator A5038296391 @default.
- W1567469571 creator A5043955471 @default.
- W1567469571 creator A5070647749 @default.
- W1567469571 date "2008-11-15" @default.
- W1567469571 modified "2023-10-16" @default.
- W1567469571 title "Oncostatin M-Induced and Constitutive Activation of the JAK2/STAT5/CIS Pathway Suppresses CCL1, but Not CCL7 and CCL8, Chemokine Expression" @default.
- W1567469571 cites W1557678369 @default.
- W1567469571 cites W1570050002 @default.
- W1567469571 cites W1586080609 @default.
- W1567469571 cites W1596383188 @default.
- W1567469571 cites W1602000691 @default.
- W1567469571 cites W1607819524 @default.
- W1567469571 cites W1631191231 @default.
- W1567469571 cites W1779691448 @default.
- W1567469571 cites W1985254009 @default.
- W1567469571 cites W1997289355 @default.
- W1567469571 cites W2000367646 @default.
- W1567469571 cites W2005376689 @default.
- W1567469571 cites W2012541226 @default.
- W1567469571 cites W2012694193 @default.
- W1567469571 cites W2020199484 @default.
- W1567469571 cites W2028325426 @default.
- W1567469571 cites W2039851322 @default.
- W1567469571 cites W2053088136 @default.
- W1567469571 cites W2054753195 @default.
- W1567469571 cites W2056967947 @default.
- W1567469571 cites W2073639128 @default.
- W1567469571 cites W2074206746 @default.
- W1567469571 cites W2083251014 @default.
- W1567469571 cites W2085580043 @default.
- W1567469571 cites W2088290283 @default.
- W1567469571 cites W2108433102 @default.
- W1567469571 cites W2111997581 @default.
- W1567469571 cites W2112791573 @default.
- W1567469571 cites W2117468155 @default.
- W1567469571 cites W2121376255 @default.
- W1567469571 cites W2129419143 @default.
- W1567469571 cites W2144737095 @default.
- W1567469571 cites W2149864650 @default.
- W1567469571 cites W2152295044 @default.
- W1567469571 cites W2156871760 @default.
- W1567469571 cites W2162422715 @default.
- W1567469571 cites W2166917491 @default.
- W1567469571 cites W2168478794 @default.
- W1567469571 cites W2169413646 @default.
- W1567469571 cites W2331800545 @default.
- W1567469571 cites W2413394956 @default.
- W1567469571 cites W4242626306 @default.
- W1567469571 cites W4313308187 @default.
- W1567469571 cites W63837087 @default.
- W1567469571 doi "https://doi.org/10.4049/jimmunol.181.10.7341" @default.
- W1567469571 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18981157" @default.
- W1567469571 hasPublicationYear "2008" @default.
- W1567469571 type Work @default.
- W1567469571 sameAs 1567469571 @default.
- W1567469571 citedByCount "27" @default.
- W1567469571 countsByYear W15674695712012 @default.
- W1567469571 countsByYear W15674695712013 @default.
- W1567469571 countsByYear W15674695712015 @default.
- W1567469571 countsByYear W15674695712016 @default.
- W1567469571 countsByYear W15674695712017 @default.
- W1567469571 countsByYear W15674695712018 @default.
- W1567469571 countsByYear W15674695712019 @default.
- W1567469571 countsByYear W15674695712021 @default.
- W1567469571 countsByYear W15674695712022 @default.
- W1567469571 countsByYear W15674695712023 @default.
- W1567469571 crossrefType "journal-article" @default.
- W1567469571 hasAuthorship W1567469571A5003694440 @default.
- W1567469571 hasAuthorship W1567469571A5008200603 @default.
- W1567469571 hasAuthorship W1567469571A5038296391 @default.
- W1567469571 hasAuthorship W1567469571A5043955471 @default.
- W1567469571 hasAuthorship W1567469571A5070647749 @default.
- W1567469571 hasBestOaLocation W15674695711 @default.
- W1567469571 hasConcept C11988809 @default.
- W1567469571 hasConcept C13164669 @default.
- W1567469571 hasConcept C13373296 @default.
- W1567469571 hasConcept C145430368 @default.
- W1567469571 hasConcept C157333092 @default.
- W1567469571 hasConcept C191732599 @default.
- W1567469571 hasConcept C203014093 @default.
- W1567469571 hasConcept C2777667943 @default.
- W1567469571 hasConcept C2778690821 @default.
- W1567469571 hasConcept C2779391668 @default.
- W1567469571 hasConcept C42362537 @default.
- W1567469571 hasConcept C502942594 @default.
- W1567469571 hasConcept C5858377 @default.
- W1567469571 hasConcept C62478195 @default.
- W1567469571 hasConcept C86803240 @default.
- W1567469571 hasConcept C8891405 @default.
- W1567469571 hasConcept C95444343 @default.
- W1567469571 hasConceptScore W1567469571C11988809 @default.
- W1567469571 hasConceptScore W1567469571C13164669 @default.
- W1567469571 hasConceptScore W1567469571C13373296 @default.
- W1567469571 hasConceptScore W1567469571C145430368 @default.