Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567475008> ?p ?o ?g. }
Showing items 1 to 56 of
56
with 100 items per page.
- W1567475008 endingPage "35" @default.
- W1567475008 startingPage "23" @default.
- W1567475008 abstract "The pharmacological effects of proctolin, [L-Dopa2]-proctolin, [Phe(OMe)2]-proctolin and [Cha(4-OMe)2]-proctolin were studied on pupae of the mealworm, Tenebrio molitor. The results were obtained by prolonged monitoring of extracardiac pulsations in haemocoelic pressure. These pulsations revealed the functions of the autonomic nervous system (coelopulse). The administration of proctolin in 100 nM to 5 µM concentrations increased the amplitude of haemocoelic pressure pulsations up to six-fold, within a few minutes. With dosages corresponding to 1 µM concentrations, the effects of proctolin culminated between the 2nd and 3rd hour post-treatment, with a successive decline to the original level within the next 15-20 hrs. The frequency of pulsations and duration of resting periods were unaffected. The [L-Dopa2]-proctolin analogue was slightly-more effective than proctolin itself, although its action was retarded for 20-30 min. The remaining two proctolin derivatives were completely inactive.Large doses of proctolin or [L-Dopa2]-proctolin (more than 5 µM concentrations in the body) produced pathophysiological symptoms of ''hyperproctolinism'', manifested by paralysis of all haemocoelic pulsations for several hours. The findings of considerable in vivo persistence of proctolin are in conflict with some general views upon the rapid inactivation of proctolin by enzymes present in the haemolymph or tissues. It is possible that proctolin may be a valid neurohormone, involved in the regulation of homeostatic physiological functions, and this is discussed." @default.
- W1567475008 created "2016-06-24" @default.
- W1567475008 creator A5028546236 @default.
- W1567475008 creator A5065612017 @default.
- W1567475008 creator A5073109475 @default.
- W1567475008 date "2013-01-01" @default.
- W1567475008 modified "2023-10-07" @default.
- W1567475008 title "Effects of proctolin on autonomic physiological functions in insects" @default.
- W1567475008 hasPublicationYear "2013" @default.
- W1567475008 type Work @default.
- W1567475008 sameAs 1567475008 @default.
- W1567475008 citedByCount "0" @default.
- W1567475008 crossrefType "journal-article" @default.
- W1567475008 hasAuthorship W1567475008A5028546236 @default.
- W1567475008 hasAuthorship W1567475008A5065612017 @default.
- W1567475008 hasAuthorship W1567475008A5073109475 @default.
- W1567475008 hasConcept C118303440 @default.
- W1567475008 hasConcept C126322002 @default.
- W1567475008 hasConcept C134018914 @default.
- W1567475008 hasConcept C150903083 @default.
- W1567475008 hasConcept C170493617 @default.
- W1567475008 hasConcept C207001950 @default.
- W1567475008 hasConcept C2777157280 @default.
- W1567475008 hasConcept C55493867 @default.
- W1567475008 hasConcept C71924100 @default.
- W1567475008 hasConcept C86803240 @default.
- W1567475008 hasConceptScore W1567475008C118303440 @default.
- W1567475008 hasConceptScore W1567475008C126322002 @default.
- W1567475008 hasConceptScore W1567475008C134018914 @default.
- W1567475008 hasConceptScore W1567475008C150903083 @default.
- W1567475008 hasConceptScore W1567475008C170493617 @default.
- W1567475008 hasConceptScore W1567475008C207001950 @default.
- W1567475008 hasConceptScore W1567475008C2777157280 @default.
- W1567475008 hasConceptScore W1567475008C55493867 @default.
- W1567475008 hasConceptScore W1567475008C71924100 @default.
- W1567475008 hasConceptScore W1567475008C86803240 @default.
- W1567475008 hasIssue "1" @default.
- W1567475008 hasLocation W15674750081 @default.
- W1567475008 hasOpenAccess W1567475008 @default.
- W1567475008 hasPrimaryLocation W15674750081 @default.
- W1567475008 hasRelatedWork W109446069 @default.
- W1567475008 hasRelatedWork W1982751517 @default.
- W1567475008 hasRelatedWork W1983622035 @default.
- W1567475008 hasRelatedWork W2032079205 @default.
- W1567475008 hasRelatedWork W2041002276 @default.
- W1567475008 hasRelatedWork W2160443306 @default.
- W1567475008 hasRelatedWork W2477070347 @default.
- W1567475008 hasRelatedWork W2802694136 @default.
- W1567475008 hasRelatedWork W3171191682 @default.
- W1567475008 hasVolume "90" @default.
- W1567475008 isParatext "false" @default.
- W1567475008 isRetracted "false" @default.
- W1567475008 magId "1567475008" @default.
- W1567475008 workType "article" @default.