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- W1567475565 abstract "Profound neurophysiologic changes occur in the course of a child's natural development from the fetal stage to the adolescent stage. Knowledge of these changes helps to guide the long-term safety assessments that are a component of pediatric drug development programs. Significant ongoing development of the brain and central nervous system (CNS) in the pediatric population warrants intense evaluation of the risks and benefits of drugs intended for this population. This chapter highlights the intricate process of nervous system development that commences in the prenatal period, with its vulnerability to drug-induced dysfunction. Tools for assessing CNS neurocognitive function can be validated and tailored for use in specific drug development programs." @default.
- W1567475565 created "2016-06-24" @default.
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- W1567475565 date "2013-07-31" @default.
- W1567475565 modified "2023-09-24" @default.
- W1567475565 title "Brain and Central Nervous System Development: Physiological Considerations for Assessment of Long-Term Safety" @default.
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- W1567475565 doi "https://doi.org/10.1002/9781118312087.ch29" @default.
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