Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567489944> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W1567489944 abstract "Macrophage inhibitory cytokine-1 (MIC-1/GDF15), a divergent member of the TGF-β superfamily, is over-expressed by many common cancers including those of the prostate (PCa) and its expression is linked to cancer outcome. We have evaluated the effect of MIC-1/GDF15 overexpression on PCa development and spread in the TRAMP transgenic model of spontaneous prostate cancer. TRAMP mice were crossed with MIC-1/GDF15 overexpressing mice (MIC-1fms) to produce syngeneic TRAMPfmsmic-1 mice. Survival rate, prostate tumor size, histopathological grades and extent of distant organ metastases were compared. Metastasis of TC1-T5, an androgen independent TRAMP cell line that lacks MIC-1/GDF15 expression, was compared by injecting intravenously into MIC-1fms and syngeneic C57BL/6 mice. Whilst TRAMPfmsmic-1 survived on average 7.4 weeks longer, had significantly smaller genitourinary (GU) tumors and lower PCa histopathological grades than TRAMP mice, more of these mice developed distant organ metastases. Additionally, a higher number of TC1-T5 lung tumor colonies were observed in MIC-1fms mice than syngeneic WT C57BL/6 mice. Our studies strongly suggest that MIC-1/GDF15 has complex actions on tumor behavior: it limits local tumor growth but may with advancing disease, promote metastases. As MIC-1/GDF15 is induced by all cancer treatments and metastasis is the major cause of cancer treatment failure and cancer deaths, these results, if applicable to humans, may have a direct impact on patient care." @default.
- W1567489944 created "2016-06-24" @default.
- W1567489944 creator A5016618979 @default.
- W1567489944 creator A5032281605 @default.
- W1567489944 creator A5036772424 @default.
- W1567489944 creator A5040495636 @default.
- W1567489944 creator A5042795113 @default.
- W1567489944 creator A5050855569 @default.
- W1567489944 creator A5054690093 @default.
- W1567489944 creator A5055198676 @default.
- W1567489944 creator A5070606019 @default.
- W1567489944 creator A5075899098 @default.
- W1567489944 creator A5078166119 @default.
- W1567489944 date "2012-08-27" @default.
- W1567489944 modified "2023-09-23" @default.
- W1567489944 title "Macrophage inhibitory cytokine-1 (MIC-1/GDF15) slows cancer development but increases metastases in TRAMP prostate cancer prone mice" @default.
- W1567489944 hasPublicationYear "2012" @default.
- W1567489944 type Work @default.
- W1567489944 sameAs 1567489944 @default.
- W1567489944 citedByCount "0" @default.
- W1567489944 crossrefType "journal-article" @default.
- W1567489944 hasAuthorship W1567489944A5016618979 @default.
- W1567489944 hasAuthorship W1567489944A5032281605 @default.
- W1567489944 hasAuthorship W1567489944A5036772424 @default.
- W1567489944 hasAuthorship W1567489944A5040495636 @default.
- W1567489944 hasAuthorship W1567489944A5042795113 @default.
- W1567489944 hasAuthorship W1567489944A5050855569 @default.
- W1567489944 hasAuthorship W1567489944A5054690093 @default.
- W1567489944 hasAuthorship W1567489944A5055198676 @default.
- W1567489944 hasAuthorship W1567489944A5070606019 @default.
- W1567489944 hasAuthorship W1567489944A5075899098 @default.
- W1567489944 hasAuthorship W1567489944A5078166119 @default.
- W1567489944 hasConcept C104177226 @default.
- W1567489944 hasConcept C121608353 @default.
- W1567489944 hasConcept C126322002 @default.
- W1567489944 hasConcept C136935669 @default.
- W1567489944 hasConcept C203014093 @default.
- W1567489944 hasConcept C2776235491 @default.
- W1567489944 hasConcept C2778690821 @default.
- W1567489944 hasConcept C2779013556 @default.
- W1567489944 hasConcept C2780192828 @default.
- W1567489944 hasConcept C2780940892 @default.
- W1567489944 hasConcept C2781182431 @default.
- W1567489944 hasConcept C502942594 @default.
- W1567489944 hasConcept C71924100 @default.
- W1567489944 hasConceptScore W1567489944C104177226 @default.
- W1567489944 hasConceptScore W1567489944C121608353 @default.
- W1567489944 hasConceptScore W1567489944C126322002 @default.
- W1567489944 hasConceptScore W1567489944C136935669 @default.
- W1567489944 hasConceptScore W1567489944C203014093 @default.
- W1567489944 hasConceptScore W1567489944C2776235491 @default.
- W1567489944 hasConceptScore W1567489944C2778690821 @default.
- W1567489944 hasConceptScore W1567489944C2779013556 @default.
- W1567489944 hasConceptScore W1567489944C2780192828 @default.
- W1567489944 hasConceptScore W1567489944C2780940892 @default.
- W1567489944 hasConceptScore W1567489944C2781182431 @default.
- W1567489944 hasConceptScore W1567489944C502942594 @default.
- W1567489944 hasConceptScore W1567489944C71924100 @default.
- W1567489944 hasOpenAccess W1567489944 @default.
- W1567489944 hasRelatedWork W1186683176 @default.
- W1567489944 hasRelatedWork W1577757266 @default.
- W1567489944 hasRelatedWork W1820863767 @default.
- W1567489944 hasRelatedWork W1969063301 @default.
- W1567489944 hasRelatedWork W1987038396 @default.
- W1567489944 hasRelatedWork W2005903270 @default.
- W1567489944 hasRelatedWork W2013068686 @default.
- W1567489944 hasRelatedWork W2019722570 @default.
- W1567489944 hasRelatedWork W2044089640 @default.
- W1567489944 hasRelatedWork W2086946515 @default.
- W1567489944 hasRelatedWork W2102790879 @default.
- W1567489944 hasRelatedWork W2137506740 @default.
- W1567489944 hasRelatedWork W2160774802 @default.
- W1567489944 hasRelatedWork W2281498192 @default.
- W1567489944 hasRelatedWork W2300801278 @default.
- W1567489944 hasRelatedWork W2415549364 @default.
- W1567489944 hasRelatedWork W2557424959 @default.
- W1567489944 hasRelatedWork W2625286871 @default.
- W1567489944 hasRelatedWork W2742616261 @default.
- W1567489944 hasRelatedWork W2896584497 @default.
- W1567489944 isParatext "false" @default.
- W1567489944 isRetracted "false" @default.
- W1567489944 magId "1567489944" @default.
- W1567489944 workType "article" @default.