Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567490798> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W1567490798 abstract "Hepatocellular carcinoma (HCC) is a type of tumor that results from chronic inflammation triggered by hepatotropic viruses or other toxic chemicals. Constitutive activation of nuclear factor (NF)-κB is an important event involved in chronic inflammation of the liver. The HBV X protein (HBx) is shown to activate NF-κB by inducing phosphorylation of IκBα and decreasing IκBα stability. Centrosomal protein P4.1-associated protein (CPAP), which plays important roles in centrosomal functions, is previously identified as the transcriptional co-activator of NF-κB. Herein, we demonstrate that CPAP can directly interact with HBx to enhance HBx-mediated NF-κB activation. Knockdown expression of CPAP abolishes this effect, indicating that CPAP is required for HBx-mediated NF-κB activation. In addition, HBx cooperates with cyclic adenosine monophosphate response element-binding protein (CREB) to increase the expression of CPAP by up-regulating its promoter activity. Furthermore, overexpression of CPAP enhances the protein stability of HBx. These results suggest that a positive feedback regulation exists between CPAP and HBx. The stable expression of CPAP in HCC cell lines increases cell proliferation. In addition, the co-expression of CPAP and HBx more greatly enhances the cell proliferation ability than either CPAP or HBx alone. Taken together, our study indicates that CPAP can cooperate with HBx and is important for HBx-induced NF-κB activation. Citation Format: Liang-Yi Hung. CPAP contributes to HBx-mediated NF-κB activation in hepatocellular carcinoma. [abstract]. In: Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr 4210. doi:10.1158/1538-7445.AM2014-4210" @default.
- W1567490798 created "2016-06-24" @default.
- W1567490798 creator A5090915612 @default.
- W1567490798 date "2014-09-30" @default.
- W1567490798 modified "2023-09-27" @default.
- W1567490798 title "Abstract 4210: CPAP contributes to HBx-mediated NF-κB activation in hepatocellular carcinoma" @default.
- W1567490798 doi "https://doi.org/10.1158/1538-7445.am2014-4210" @default.
- W1567490798 hasPublicationYear "2014" @default.
- W1567490798 type Work @default.
- W1567490798 sameAs 1567490798 @default.
- W1567490798 citedByCount "0" @default.
- W1567490798 crossrefType "proceedings-article" @default.
- W1567490798 hasAuthorship W1567490798A5090915612 @default.
- W1567490798 hasConcept C121608353 @default.
- W1567490798 hasConcept C126322002 @default.
- W1567490798 hasConcept C173396325 @default.
- W1567490798 hasConcept C185592680 @default.
- W1567490798 hasConcept C2776914184 @default.
- W1567490798 hasConcept C2777730290 @default.
- W1567490798 hasConcept C2778019345 @default.
- W1567490798 hasConcept C502942594 @default.
- W1567490798 hasConcept C54009773 @default.
- W1567490798 hasConcept C54355233 @default.
- W1567490798 hasConcept C555283112 @default.
- W1567490798 hasConcept C62478195 @default.
- W1567490798 hasConcept C67567795 @default.
- W1567490798 hasConcept C71924100 @default.
- W1567490798 hasConcept C81885089 @default.
- W1567490798 hasConcept C86803240 @default.
- W1567490798 hasConcept C95444343 @default.
- W1567490798 hasConceptScore W1567490798C121608353 @default.
- W1567490798 hasConceptScore W1567490798C126322002 @default.
- W1567490798 hasConceptScore W1567490798C173396325 @default.
- W1567490798 hasConceptScore W1567490798C185592680 @default.
- W1567490798 hasConceptScore W1567490798C2776914184 @default.
- W1567490798 hasConceptScore W1567490798C2777730290 @default.
- W1567490798 hasConceptScore W1567490798C2778019345 @default.
- W1567490798 hasConceptScore W1567490798C502942594 @default.
- W1567490798 hasConceptScore W1567490798C54009773 @default.
- W1567490798 hasConceptScore W1567490798C54355233 @default.
- W1567490798 hasConceptScore W1567490798C555283112 @default.
- W1567490798 hasConceptScore W1567490798C62478195 @default.
- W1567490798 hasConceptScore W1567490798C67567795 @default.
- W1567490798 hasConceptScore W1567490798C71924100 @default.
- W1567490798 hasConceptScore W1567490798C81885089 @default.
- W1567490798 hasConceptScore W1567490798C86803240 @default.
- W1567490798 hasConceptScore W1567490798C95444343 @default.
- W1567490798 hasLocation W15674907981 @default.
- W1567490798 hasOpenAccess W1567490798 @default.
- W1567490798 hasPrimaryLocation W15674907981 @default.
- W1567490798 hasRelatedWork W1817869836 @default.
- W1567490798 hasRelatedWork W1968441550 @default.
- W1567490798 hasRelatedWork W1992128337 @default.
- W1567490798 hasRelatedWork W1993384459 @default.
- W1567490798 hasRelatedWork W1998039589 @default.
- W1567490798 hasRelatedWork W2042862476 @default.
- W1567490798 hasRelatedWork W2043515134 @default.
- W1567490798 hasRelatedWork W2074210006 @default.
- W1567490798 hasRelatedWork W2103362490 @default.
- W1567490798 hasRelatedWork W2108435909 @default.
- W1567490798 hasRelatedWork W2114312215 @default.
- W1567490798 hasRelatedWork W2154646566 @default.
- W1567490798 hasRelatedWork W2170998280 @default.
- W1567490798 hasRelatedWork W2188801436 @default.
- W1567490798 hasRelatedWork W2315233266 @default.
- W1567490798 hasRelatedWork W2463476332 @default.
- W1567490798 hasRelatedWork W2530015186 @default.
- W1567490798 hasRelatedWork W3124973769 @default.
- W1567490798 hasRelatedWork W3152886637 @default.
- W1567490798 hasRelatedWork W3210186628 @default.
- W1567490798 isParatext "false" @default.
- W1567490798 isRetracted "false" @default.
- W1567490798 magId "1567490798" @default.
- W1567490798 workType "article" @default.