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- W156756572 abstract "ABSTRACT The relationship of phospholipid composition and mitochondrial assembly and function is discussed. The phospholipid composition, with particular reference to cardiolipin content of yeast under a variety of physiological conditions is related to mitochondrial function. Variations in cardiolipin content appear to be partially attributable to modulation of its degradation. Cardiolipin accumulation is episodic in synchronized yeast occurring at the time of DNA synthesis. However, much of the accumulated cardiolipin is degraded in synchronized cells grown in glucose while it is retained in those grown in galactose. Attempts have been made to utilize mutants in lipid synthesis to study mitochondrial assembly and function. Using an unsaturated fatty acid auxotroph, cells supplemented with trans unsaturated fatty acid have a specific defect in cytochrome oxidase activity and content compared to cells supplemented with the cis unsaturated fatty acid of the same chain length. The cytoplasmic subunits of cytochrome c oxidase appear to be preferentially decreased. KEYWORDS Phospholipid;, mitochondria;, cardiolipin;, unsaturated fatty acid;, synchronized yeast;, phospholipid degradation." @default.
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- W156756572 date "1981-01-01" @default.
- W156756572 modified "2023-09-26" @default.
- W156756572 title "THE ROLE OF PHOSPHOLIPIDS IN THE BIOGENESIS OF MITOCHONDRIA AND YEAST" @default.
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- W156756572 doi "https://doi.org/10.1016/b978-0-08-025382-4.50054-x" @default.
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