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• W1567604499 abstract "Research Article15 June 1994free access Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15. J.G. Giri J.G. Giri Immunex Research and Development Corporation, Seattle, WA 98101. Search for more papers by this author M. Ahdieh M. Ahdieh Immunex Research and Development Corporation, Seattle, WA 98101. Search for more papers by this author J. Eisenman J. Eisenman Immunex Research and Development Corporation, Seattle, WA 98101. Search for more papers by this author K. Shanebeck K. Shanebeck Immunex Research and Development Corporation, Seattle, WA 98101. Search for more papers by this author K. Grabstein K. Grabstein Immunex Research and Development Corporation, Seattle, WA 98101. Search for more papers by this author S. Kumaki S. Kumaki Immunex Research and Development Corporation, Seattle, WA 98101. Search for more papers by this author A. Namen A. Namen Immunex Research and Development Corporation, Seattle, WA 98101. Search for more papers by this author L.S. Park L.S. Park Immunex Research and Development Corporation, Seattle, WA 98101. Search for more papers by this author D. Cosman D. Cosman Immunex Research and Development Corporation, Seattle, WA 98101. Search for more papers by this author D. Anderson D. Anderson Immunex Research and Development Corporation, Seattle, WA 98101. Search for more papers by this author J.G. Giri J.G. Giri Immunex Research and Development Corporation, Seattle, WA 98101. Search for more papers by this author M. Ahdieh M. Ahdieh Immunex Research and Development Corporation, Seattle, WA 98101. Search for more papers by this author J. Eisenman J. Eisenman Immunex Research and Development Corporation, Seattle, WA 98101. Search for more papers by this author K. Shanebeck K. Shanebeck Immunex Research and Development Corporation, Seattle, WA 98101. Search for more papers by this author K. Grabstein K. Grabstein Immunex Research and Development Corporation, Seattle, WA 98101. Search for more papers by this author S. Kumaki S. Kumaki Immunex Research and Development Corporation, Seattle, WA 98101. Search for more papers by this author A. Namen A. Namen Immunex Research and Development Corporation, Seattle, WA 98101. Search for more papers by this author L.S. Park L.S. Park Immunex Research and Development Corporation, Seattle, WA 98101. Search for more papers by this author D. Cosman D. Cosman Immunex Research and Development Corporation, Seattle, WA 98101. Search for more papers by this author D. Anderson D. Anderson Immunex Research and Development Corporation, Seattle, WA 98101. Search for more papers by this author Author Information J.G. Giri1, M. Ahdieh1, J. Eisenman1, K. Shanebeck1, K. Grabstein1, S. Kumaki1, A. Namen1, L.S. Park1, D. Cosman1 and D. Anderson1 1Immunex Research and Development Corporation, Seattle, WA 98101. The EMBO Journal (1994)13:2822-2830https://doi.org/10.1002/j.1460-2075.1994.tb06576.x PDFDownload PDF of article text and main figures. ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinked InMendeleyWechatReddit Figures & Info We have recently cloned a novel cytokine, IL-15, with shared bioactivities but no sequence homology with IL-2. We found high affinity IL-15 binding to many cell types, including cells of non-lymphoid origin. Analysis of IL-15 interaction with subunits of the IL-2 receptor (IL-2R) revealed that the alpha subunit was not involved in IL-15 binding. We demonstrated directly in cells transfected with IL-2R subunits that both the beta and gamma chains are required for IL-15 binding and signaling. Hence, IL-15, like IL-2, IL-4 and IL-7, utilizes the common IL-2R gamma subunit found to be defective in X-linked severe combined immunodeficiency in humans. IL-15 is the only cytokine other than IL-2 that has also been shown to share the beta signaling subunit of IL-2R. The differential ability of some cells to bind and respond to IL-2 and IL-15 implies the existence of an additional IL-15-specific component. Previous ArticleNext Article Volume 13Issue 121 June 1994In this issue RelatedDetailsLoading ..." @default.
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• W1567604499 title "Utilization of the beta and gamma chains of the IL-2 receptor by the novel cytokine IL-15." @default.
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