FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567604666> ?p ?o ?g. }

• W1567604666 endingPage "e0134145" @default.
• W1567604666 startingPage "e0134145" @default.
• W1567604666 abstract "The aim of present study was to investigate the effects of ammonium ions on in vitro neuronal network activity and to search alternative methods of acute ammonia neurotoxicity prevention.Rat hippocampal neuronal and astrocytes co-cultures in vitro, fluorescent microscopy and perforated patch clamp were used to monitor the changes in intracellular Ca2+- and membrane potential produced by ammonium ions and various modulators in the cells implicated in neural networks.Low concentrations of NH4Cl (0.1-4 mM) produce short temporal effects on network activity. Application of 5-8 mM NH4Cl: invariably transforms diverse network firing regimen to identical burst patterns, characterized by substantial neuronal membrane depolarization at plateau phase of potential and high-amplitude Ca2+-oscillations; raises frequency and average for period of oscillations Ca2+-level in all cells implicated in network; results in the appearance of group of «run out» cells with high intracellular Ca2+ and steadily diminished amplitudes of oscillations; increases astrocyte Ca2+-signalling, characterized by the appearance of groups of cells with increased intracellular Ca2+-level and/or chaotic Ca2+-oscillations. Accelerated network activity may be suppressed by the blockade of NMDA or AMPA/kainate-receptors or by overactivation of AMPA/kainite-receptors. Ammonia still activate neuronal firing in the presence of GABA(A) receptors antagonist bicuculline, indicating that «disinhibition phenomenon» is not implicated in the mechanisms of networks acceleration. Network activity may also be slowed down by glycine, agonists of metabotropic inhibitory receptors, betaine, L-carnitine, L-arginine, etc.Obtained results demonstrate that ammonium ions accelerate neuronal networks firing, implicating ionotropic glutamate receptors, having preserved the activities of group of inhibitory ionotropic and metabotropic receptors. This may mean, that ammonia neurotoxicity might be prevented by the activation of various inhibitory receptors (i.e. by the reinforcement of negative feedback control), instead of application of various enzyme inhibitors and receptor antagonists (breaking of neural, metabolic and signaling systems)." @default.
• W1567604666 created "2016-06-24" @default.
• W1567604666 creator A5021051328 @default.
• W1567604666 creator A5036783532 @default.
• W1567604666 creator A5047584270 @default.
• W1567604666 creator A5064964536 @default.
• W1567604666 creator A5072378868 @default.
• W1567604666 creator A5088411495 @default.
• W1567604666 date "2015-07-28" @default.
• W1567604666 modified "2023-10-17" @default.
• W1567604666 title "To Break or to Brake Neuronal Network Accelerated by Ammonium Ions?" @default.
• W1567604666 cites W117488228 @default.
• W1567604666 cites W1513934328 @default.
• W1567604666 cites W1546368456 @default.
• W1567604666 cites W1549403331 @default.
• W1567604666 cites W1594663117 @default.
• W1567604666 cites W1772557960 @default.
• W1567604666 cites W1903340256 @default.
• W1567604666 cites W1916047164 @default.
• W1567604666 cites W1964279532 @default.
• W1567604666 cites W1969677266 @default.
• W1567604666 cites W1970718497 @default.
• W1567604666 cites W1971050542 @default.
• W1567604666 cites W1971256693 @default.
• W1567604666 cites W1971829840 @default.
• W1567604666 cites W1971931358 @default.
• W1567604666 cites W1975963491 @default.
• W1567604666 cites W1976314545 @default.
• W1567604666 cites W1977109693 @default.
• W1567604666 cites W1978563375 @default.
• W1567604666 cites W1979657613 @default.
• W1567604666 cites W1986729839 @default.
• W1567604666 cites W1988636131 @default.
• W1567604666 cites W1988764052 @default.
• W1567604666 cites W1991817028 @default.
• W1567604666 cites W1991844775 @default.
• W1567604666 cites W1994555844 @default.
• W1567604666 cites W1995830387 @default.
• W1567604666 cites W1997865219 @default.
• W1567604666 cites W2000756368 @default.
• W1567604666 cites W2006376420 @default.
• W1567604666 cites W2007456064 @default.
• W1567604666 cites W2011473644 @default.
• W1567604666 cites W2012975925 @default.
• W1567604666 cites W2014381155 @default.
• W1567604666 cites W2014583604 @default.
• W1567604666 cites W2015660262 @default.
• W1567604666 cites W2019083363 @default.
• W1567604666 cites W2023845618 @default.
• W1567604666 cites W2026827035 @default.
• W1567604666 cites W2036563843 @default.
• W1567604666 cites W2040507979 @default.
• W1567604666 cites W2040532119 @default.
• W1567604666 cites W2042768109 @default.
• W1567604666 cites W2047172111 @default.
• W1567604666 cites W2047284784 @default.
• W1567604666 cites W2047556028 @default.
• W1567604666 cites W2047927259 @default.
• W1567604666 cites W2048119485 @default.
• W1567604666 cites W2049224437 @default.
• W1567604666 cites W2053109438 @default.
• W1567604666 cites W2055102381 @default.
• W1567604666 cites W2055636563 @default.
• W1567604666 cites W2059329631 @default.
• W1567604666 cites W2059404591 @default.
• W1567604666 cites W2060040098 @default.
• W1567604666 cites W2068911533 @default.
• W1567604666 cites W2068942851 @default.
• W1567604666 cites W2075853825 @default.
• W1567604666 cites W2079216695 @default.
• W1567604666 cites W2083995327 @default.
• W1567604666 cites W2085920222 @default.
• W1567604666 cites W2086333383 @default.
• W1567604666 cites W2092156727 @default.
• W1567604666 cites W2093301371 @default.
• W1567604666 cites W2093857021 @default.
• W1567604666 cites W2099717623 @default.
• W1567604666 cites W2100586833 @default.
• W1567604666 cites W2104703549 @default.
• W1567604666 cites W2105129861 @default.
• W1567604666 cites W2108695816 @default.
• W1567604666 cites W2111404538 @default.
• W1567604666 cites W2114961808 @default.
• W1567604666 cites W2116386279 @default.
• W1567604666 cites W2116713648 @default.
• W1567604666 cites W2118281941 @default.
• W1567604666 cites W2125670128 @default.
• W1567604666 cites W2133955734 @default.
• W1567604666 cites W2142533597 @default.
• W1567604666 cites W2142918026 @default.
• W1567604666 cites W2148428950 @default.
• W1567604666 cites W2151488696 @default.
• W1567604666 cites W2163061108 @default.
• W1567604666 cites W2169568834 @default.
• W1567604666 cites W2171737165 @default.
• W1567604666 cites W2184441833 @default.
• W1567604666 cites W220771428 @default.
• W1567604666 cites W2251375544 @default.

• next