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• W1567638684 abstract "We studied the effects of infusion of a branched chain enriched amino acid mixture versus glucose on acute hepatic encephalopathy in patients with cirrhosis. Sixty-five patients were randomly treated with 1 g/kg per day of an amino acid mixture with 40% branched chain contents (32 patients), or isocaloric glucose (33 patients) for a maximum of 16 days. The regimens further included glucose infusion to a total of 26.5 kcal/kg per day and lactulose. The patients took part in the study for 5–6 days. In each group 17 patients woke up. In the amino acid group eleven died and four developed renal failure. In the glucose group ten died, three developed renal and two respiratory failure, and one remained encephalopathic. The coma score worsened in three of the patients who died in the amino acid group, but in all patients who died in the glucose group. The negative nitrogen balance on entry reversed in the amino acid group, but not in the glucose group. Thus, the branched chain enriched amino acid supplement did not change the prognosis for wake-up, but had other effects on the cerebral state and on nitrogen homeostasis." @default.
• W1567638684 created "2016-06-24" @default.
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• W1567638684 date "1990-05-01" @default.
• W1567638684 modified "2023-10-18" @default.
• W1567638684 title "Branched chain enriched amino acid versus glucose treatment of hepatic encephalopathy" @default.
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• W1567638684 doi "https://doi.org/10.1016/0168-8278(90)90135-e" @default.
• W1567638684 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2195106" @default.
• W1567638684 hasPublicationYear "1990" @default.
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