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- W1567647760 abstract "Abstract Thymectomy of BALB/c mice on day 3 of life results in the development of autoimmune gastritis (AIG) due to the absence of CD4+CD25+ regulatory T cells. However, depletion of CD4+CD25+ T cells by treatment with anti-CD25 rarely resulted in AIG. Depletion was efficient, as transfer of splenocytes from depleted mice induced AIG in nu/nu mice. One explanation for this result is that CD4+CD25− T cells upon transfer to nude recipients undergo lymphopenia-induced proliferation, providing a signal for T cell activation. Cotransfer of CD25+ T cells did not inhibit initial proliferation but did suppress AIG. Surprisingly, immunization with the AIG target Ag, H/K ATPase, in IFA failed to induce disease in normal animals but induced severe AIG in CD25-depleted mice. These results demonstrate that second signals (nonspecific proliferation, TCR activation, or inflammation) are needed for induction of autoimmunity in the absence of CD25+ regulatory T cells." @default.
- W1567647760 created "2016-06-24" @default.
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- W1567647760 date "2002-06-15" @default.
- W1567647760 modified "2023-10-17" @default.
- W1567647760 title "Cutting Edge: Depletion of CD4+CD25+ Regulatory T Cells Is Necessary, But Not Sufficient, for Induction of Organ-Specific Autoimmune Disease" @default.
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- W1567647760 doi "https://doi.org/10.4049/jimmunol.168.12.5979" @default.
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