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- W1567649437 abstract "textabstractBlood consists of serum and three other main ingredients: erythrocytes (red bloodcells), thrombocytes (platelets) and leukocytes (white blood cells). Leukocytesnormally compose less than 1% of the blood volume but have important functionsin our defense against foreign and endogenous pathogens. Many differentleukocytes can be distinguished, the main types being lymphocytes (~75% T-cells,~25% B-cells), monocytes and granulocytes. All these different blood cells arisethrough distinct and tightly controlled developmental stages from hematopoieticprecursor cells, which reside in the bone marrow and thymus (Figure 1). However,sequential mutations, chromosomal rearrangements and epigenetic changes cancause a precursor cell to be blocked from further differentiation and to startproliferate in a uncontrollable manner which results in cancer. Uncontrolledproliferation of blood precursor cells is called leukemia. Different types ofleukemia are distinguished based on their lineage of origin; myeloid orlymphoblastic leukemia. Lymphoblastic leukemia can be further divided into Bcellprecursor (BCP) or T-cell lymphoblastic leukemia. In acute lymphoblasticleukemia malignant cells are arrested at a relative immature stage whereas inchronic lymphocytic leukemia, cells have a more differentiated phenotype." @default.
- W1567649437 created "2016-06-24" @default.
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- W1567649437 date "2011-11-30" @default.
- W1567649437 modified "2023-09-24" @default.
- W1567649437 title "Gene-expression profiles and oncogenes in pediatric T-cell acute lymphoblastic leukemia" @default.
- W1567649437 hasPublicationYear "2011" @default.
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