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- W1567651139 abstract "We thank Professor Bassotti for his interest in our paper.1, 2 Adverse reactions to gluten consumption are not limited to subjects suffering from coeliac disease. Presently, non-coeliac gluten sensitivity is increasingly being clinically recognised as a separate condition, in which subjects experience symptoms after gluten ingestion, identical to those seen in coeliac disease.3-6 AN-PEP has been developed as a dietary supplement that may help to digest unintended dietary gluten for all subjects intolerant to gluten. To investigate the efficacy of AN-PEP on gastrointestinal gluten degradation in healthy volunteers, as well as the effect of meal caloric density on AN-PEP efficiency, we made use of a triple lumen nasoduodenal catheter. We would like to correct the misconception that the catheter was positioned for 48 h on two separate occasions; it was inserted at start of each test day and removed 5 h later, in total on four separate occasions. It enabled us to simultaneously administer the test meal, infuse a dilution marker and aspirate gastric and duodenal contents. We choose to administer the test meal intragastrically at a standardised rate, to avoid differences in gluten degradation caused by variable meal ingestion rates. Results of our study are promising and it is important that in future studies the efficacy of AN-PEP will be investigated in an actual meal setting, in which AN-PEP is consumed as a dietary supplement with a meal that contains unintentional small amounts of gluten, in subjects intolerant to gluten. The authors’ declarations of personal and financial interests are unchanged from those in the original article.2" @default.
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- W1567651139 date "2015-07-14" @default.
- W1567651139 modified "2023-09-26" @default.
- W1567651139 title "Editorial: enhancing gluten digestion in the stomach - a further help to minimise unintentional ingestion? Authors’ reply" @default.
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- W1567651139 doi "https://doi.org/10.1111/apt.13296" @default.
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