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- W1567659578 abstract "Improved understanding of the inflammatory response and the identification and characterization of the specific cytokines involved, as well as improved understanding of erythropoiesis, and the availability of recombinant human growth factors such as EPO, have greatly enhanced our appreciation of the pathogenesis of ACD by allowing development of a number of informative models for studying this syndrome. It appears that a variety of cytokines are involved in all aspects of the pathogenesis of ACD, from the inhibition of erythroid progenitors and EPO production to impairment of iron release. A schematic of the contributions of some of these cytokines to the development of ACD is shown in Fig 6. The exact biochemical mechanisms by which these effects occur is still to be determined. The progress outlined in this report has allowed us to develop a more precise understanding of the pathogenesis of this common and important clinical syndrome. In 1983, Hansen subtitled a review of ACD “A Bag of Unsolved Questions.” Although this description is still accurate, our understanding of ACD has now developed to the point where we can offer a more defined subtitle: “A Bag of Cytokines.”" @default.
- W1567659578 created "2016-06-24" @default.
- W1567659578 creator A5028621466 @default.
- W1567659578 creator A5087510374 @default.
- W1567659578 date "1992-10-01" @default.
- W1567659578 modified "2023-10-16" @default.
- W1567659578 title "Progress in understanding the pathogenesis of the anemia of chronic disease [see comments]" @default.
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- W1567659578 doi "https://doi.org/10.1182/blood.v80.7.1639.bloodjournal8071639" @default.
- W1567659578 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1391934" @default.
- W1567659578 hasPublicationYear "1992" @default.
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