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- W1567661393 abstract "n 1970, experimental infection of gram-free chickens with an avian herpes virus was found to produce arterial disease that resembled human atherosclerosis. From that time several studies were done on Helicobacter pylori (H. pylori) , Chlamydia pneumoniae (Ch. Pnemoniae), cytomegalovirus 1 and periodontal infections, which had different results. In 1994, Mendall et al 2 reported for the first time an association between H. pylori infection and coronary artery disease (CAD). After that, several studies were performed which confirmed Mendall's theory 3 while some rejected the theory. 4 Several studies have provided evidence for a causal relationship between H. pylori and CAD. It has been hypothesized that H. pylori -associated chronic inflammation of the gastric mucosa leads to elevated plasma levels of fibrinogen, C-reactive protein and leukocytes. Other hypotheses include gastritis induced vitamin B-12 deficiency, leading to hyperhomocysteinanemia. The suggested mechanism for Ch. pneumoniae is the direct effect of this microorganism on the intima of vessels. 5 Despite many studies, which have been performed to prove the association between the causative role of H. pylori and Ch. pneumoniae in atherosclerosis, there are still many controversies which remain. Two problems are observed in many of the studies, which has been carried out up to now. Firstly, only half of the studies, CAD was proved by angiography while in the other half, CAD was diagnosed by other means such as history, electrocardiogram or other non-reliable diagnostic tests. The other problem was the lack of homogeneity in the population selected for the studies. Socioeconomic level is one of the important factors that is related to both CAD risk factors and the incidence of H. pylori and Ch. pneumoniae infection and this factor was not foreseen in many of the studies. In this study, we investigated the seroprevalence of H. pylori and Ch. pneumoniae infection in patients with proved CAD and in normal population. The population selected for the study I" @default.
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- W1567661393 date "2005-04-01" @default.
- W1567661393 modified "2023-09-23" @default.
- W1567661393 title "Association between angiographic evidence of coronary artery disease and seropositivity for Helicobacter pylori and Chlamydia pneumoniae infection." @default.
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