FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567663742> ?p ?o ?g. }

• W1567663742 abstract "of a thesis at the University of Miami. Thesis supervised by Professor Mary Lou King. No. of pages in text. (41) The spatio-temporal regulation of translation is critical to the proper development of all organisms. The presence of Translational Control Elements (TCEs) in Un-Translated Regions (UTRs) is one feature common to all regulated eukaryotic mRNAs examined to date. These TCEs serve as binding sites for sequence specific proteins or small regulatory RNAs that recruit other accessory proteins that inhibit translation. Xnos1, a localized RNA in the germ plasm of Xenopus, is negatively regulated by an unknown mechanism. We used in vivo and in vitro translation assays, competition assays, and ribosome binding assays in order to determine the location of the Xnos1 TCE and its mechanism of repression. The Xnos1 TCE is located in the open reading frame, a departure from the canonical translational regulation mechanisms. This TCE is predicted to form conserved secondary structures in the first 75 nucleotides of the open reading frame (ORF). In vitro translation assays demonstrated that the repression can be partially relieved by either denaturing the transcripts or by introducing point mutations that weaken the secondary structure. This TCE cannot be relieved by competition and therefore is likely not to require the presence of a repressor protein. The structural regulation of translation by a TCE in the open reading frame is a novel mechanism of repression for a eukaryotic mRNA." @default.
• W1567663742 created "2016-06-24" @default.
• W1567663742 creator A5045370513 @default.
• W1567663742 date "2008-01-01" @default.
• W1567663742 modified "2023-09-23" @default.
• W1567663742 title "Inhibition of Xnos1 Translation by Structural Elementsin the Open Reading Frame" @default.
• W1567663742 cites W1546686895 @default.
• W1567663742 cites W1972412809 @default.
• W1567663742 cites W1974822125 @default.
• W1567663742 cites W1978885095 @default.
• W1567663742 cites W1993650200 @default.
• W1567663742 cites W1997609839 @default.
• W1567663742 cites W2000124004 @default.
• W1567663742 cites W2000269997 @default.
• W1567663742 cites W2000426354 @default.
• W1567663742 cites W2003798205 @default.
• W1567663742 cites W2006691081 @default.
• W1567663742 cites W2010411090 @default.
• W1567663742 cites W2011090354 @default.
• W1567663742 cites W2011230039 @default.
• W1567663742 cites W2022397266 @default.
• W1567663742 cites W2035030706 @default.
• W1567663742 cites W2037515198 @default.
• W1567663742 cites W2044595289 @default.
• W1567663742 cites W2047784091 @default.
• W1567663742 cites W2049066372 @default.
• W1567663742 cites W2063173391 @default.
• W1567663742 cites W2068224181 @default.
• W1567663742 cites W2072971665 @default.
• W1567663742 cites W2075511135 @default.
• W1567663742 cites W2078142069 @default.
• W1567663742 cites W2082592915 @default.
• W1567663742 cites W2092416835 @default.
• W1567663742 cites W2095498511 @default.
• W1567663742 cites W2103569587 @default.
• W1567663742 cites W2111578570 @default.
• W1567663742 cites W2111989690 @default.
• W1567663742 cites W2120235608 @default.
• W1567663742 cites W2126036680 @default.
• W1567663742 cites W2141157874 @default.
• W1567663742 cites W2159107837 @default.
• W1567663742 cites W2161021693 @default.
• W1567663742 cites W2166840544 @default.
• W1567663742 cites W2183735793 @default.
• W1567663742 cites W2412086007 @default.
• W1567663742 hasPublicationYear "2008" @default.
• W1567663742 type Work @default.
• W1567663742 sameAs 1567663742 @default.
• W1567663742 citedByCount "0" @default.
• W1567663742 crossrefType "journal-article" @default.
• W1567663742 hasAuthorship W1567663742A5045370513 @default.
• W1567663742 hasConcept C104317684 @default.
• W1567663742 hasConcept C105580179 @default.
• W1567663742 hasConcept C149364088 @default.
• W1567663742 hasConcept C150194340 @default.
• W1567663742 hasConcept C166258313 @default.
• W1567663742 hasConcept C167625842 @default.
• W1567663742 hasConcept C186310378 @default.
• W1567663742 hasConcept C39685955 @default.
• W1567663742 hasConcept C47289529 @default.
• W1567663742 hasConcept C54355233 @default.
• W1567663742 hasConcept C70721500 @default.
• W1567663742 hasConcept C86803240 @default.
• W1567663742 hasConcept C95444343 @default.
• W1567663742 hasConceptScore W1567663742C104317684 @default.
• W1567663742 hasConceptScore W1567663742C105580179 @default.
• W1567663742 hasConceptScore W1567663742C149364088 @default.
• W1567663742 hasConceptScore W1567663742C150194340 @default.
• W1567663742 hasConceptScore W1567663742C166258313 @default.
• W1567663742 hasConceptScore W1567663742C167625842 @default.
• W1567663742 hasConceptScore W1567663742C186310378 @default.
• W1567663742 hasConceptScore W1567663742C39685955 @default.
• W1567663742 hasConceptScore W1567663742C47289529 @default.
• W1567663742 hasConceptScore W1567663742C54355233 @default.
• W1567663742 hasConceptScore W1567663742C70721500 @default.
• W1567663742 hasConceptScore W1567663742C86803240 @default.
• W1567663742 hasConceptScore W1567663742C95444343 @default.
• W1567663742 hasOpenAccess W1567663742 @default.
• W1567663742 hasRelatedWork W1633323969 @default.
• W1567663742 hasRelatedWork W2016043308 @default.
• W1567663742 hasRelatedWork W2113744760 @default.
• W1567663742 hasRelatedWork W2141049773 @default.
• W1567663742 hasRelatedWork W2150704115 @default.
• W1567663742 hasRelatedWork W2255242978 @default.
• W1567663742 hasRelatedWork W2613678666 @default.
• W1567663742 hasRelatedWork W2737298450 @default.
• W1567663742 hasRelatedWork W2809277035 @default.
• W1567663742 hasRelatedWork W2912045231 @default.
• W1567663742 hasRelatedWork W2952214797 @default.
• W1567663742 hasRelatedWork W2954498629 @default.
• W1567663742 hasRelatedWork W3022862968 @default.
• W1567663742 hasRelatedWork W3035488122 @default.
• W1567663742 hasRelatedWork W3091954298 @default.
• W1567663742 hasRelatedWork W3122284665 @default.
• W1567663742 hasRelatedWork W639440538 @default.
• W1567663742 hasRelatedWork W750540276 @default.
• W1567663742 hasRelatedWork W2186543380 @default.
• W1567663742 hasRelatedWork W2740273028 @default.
• W1567663742 isParatext "false" @default.
• W1567663742 isRetracted "false" @default.

• next