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- W1567663756 abstract "Currently, resistant-melancholic depression is an important public health, economic and working problem. In the last years, different strategies of augmentation (with non-antidepressants drugs) and combination (antidepressants with different neurochemical profiles) have been developed. Also, several studies of treatment-response have been played (ex. Sequenced Treatment Alternatives to Relieve Depression- STAR*D), and treatment algorithms for the management of nonresponders patients have been developed (ex. Grupo para el Estudio de las Asociaciones de Antidepresivos-GEAA, turkish algorithm). The combination of antidepressants has turned from an heterodoxal, marginal practice, to be consider nowadays as a valid practice in the first or second step of treatment algorithms. Some authors include combination strategies in the first step of treatment for resistant-melancholia and delusional depression: The goal of treatment is to reach complete remission, not response. The pharmacological and clinical basis of the combination strategies are layed on neurochemical complementarity; sinergystic effect (1 + 1 = 10); improvement of tolerability and security; and clinical daily-setting, naturalistic practice experiences. We review in this article some features of the combination venlafaxine plus mirtazapine (that we call “hard-artillery”). This combination obtains a triple serotoninergic boost and a double noradrenergic boost, with high rates of efficacy and reasonable margins of tolerability and security. Finally, several studies concerning this combination are collected and discussed." @default.
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- W1567663756 date "2010-01-01" @default.
- W1567663756 modified "2023-09-24" @default.
- W1567663756 title "Bases farmacológicas y clínicas de la combinación venlafaxina + mirtazapina en depresión melancólica: la artillería pesada" @default.
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