FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567671145> ?p ?o ?g. }

• W1567671145 endingPage "391" @default.
• W1567671145 startingPage "386" @default.
• W1567671145 abstract "The psychoneuroimmunology of panic disorder is relatively unexplored. Alterations within brain stress systems that secondarily influence the immune system have been documented. A recent report indicated elevations of serotonin (5-HT) and ganglioside antibodies in patients with primary fibromyalgia, a condition with documented associations with panic disorder. In line with our interest in dysregulated 5-HT systems in panic disorder (PD), we wished to assess if antibodies directed at the 5-HT system were elevated in patients with PD in comparison to healthy volunteers. Sixty-three patients with panic disorder and 26 healthy volunteers were diagnosed by the SCID. Employing ELISA, we measured anti-5-HT and 5-HT anti-idiotypic antibodies (which are directed at 5-HT receptors). To include all subjects in one experiment, three different batches were run during the ELISA. Plasma serotonin anti-idiotypic antibodies: there was a significant group effect [patients > controls (p = .007)] and batch effect but no interaction. The mean effect size for the three batches was .76. Following Z-score transformation of each separate batch and then combining all scores, patients demonstrated significantly elevated levels of plasma serotonin anti-idiotypic antibodies. Neither sex nor age as covariates affected the significance of the results. There was a strong correlation between anti-serotonin antibody and serotonin anti-idiotypic antibody measures. Plasma anti-serotonin antibodies: there was a significant diagnosis effect [patients > controls (p = .037)]. Mean effect size for the three batches was .52. Upon Z-score transformation, there was a diagnosis effect with antibody elevations in patients. Covaried for sex and age, the result falls below significance to trend levels. The data raise the possibility that psychoimmune dysfunction, specifically related to the 5-HT system, may be present in PD. Potential interruption of 5-HT neurotransmission through autoimmune mechanisms may be of pathophysiologic significance in certain patients with panic disorder. It remains to be demonstrated if the peripheral autoimmunity is representative of CNS 5-HT neuronal alterations. Replication appears warranted." @default.
• W1567671145 created "2016-06-24" @default.
• W1567671145 creator A5003370819 @default.
• W1567671145 creator A5004959719 @default.
• W1567671145 creator A5010000360 @default.
• W1567671145 creator A5026564126 @default.
• W1567671145 creator A5051404866 @default.
• W1567671145 creator A5060032203 @default.
• W1567671145 creator A5064462389 @default.
• W1567671145 creator A5073081812 @default.
• W1567671145 creator A5080357880 @default.
• W1567671145 date "1999-04-01" @default.
• W1567671145 modified "2023-09-26" @default.
• W1567671145 title "Plasma Anti-Serotonin and Serotonin Anti-Idiotypic Antibodies Are Elevated in Panic Disorder" @default.
• W1567671145 cites W1688439786 @default.
• W1567671145 cites W1965890581 @default.
• W1567671145 cites W1966101354 @default.
• W1567671145 cites W1971842754 @default.
• W1567671145 cites W1980121571 @default.
• W1567671145 cites W1993856151 @default.
• W1567671145 cites W1998218746 @default.
• W1567671145 cites W2008946516 @default.
• W1567671145 cites W2034542271 @default.
• W1567671145 cites W2076027411 @default.
• W1567671145 cites W2079956181 @default.
• W1567671145 cites W2104308931 @default.
• W1567671145 cites W2112673617 @default.
• W1567671145 cites W94361130 @default.
• W1567671145 doi "https://doi.org/10.1016/s0893-133x(98)00130-4" @default.
• W1567671145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10088140" @default.
• W1567671145 hasPublicationYear "1999" @default.
• W1567671145 type Work @default.
• W1567671145 sameAs 1567671145 @default.
• W1567671145 citedByCount "28" @default.
• W1567671145 countsByYear W15676711452013 @default.
• W1567671145 countsByYear W15676711452014 @default.
• W1567671145 countsByYear W15676711452015 @default.
• W1567671145 countsByYear W15676711452016 @default.
• W1567671145 countsByYear W15676711452019 @default.
• W1567671145 countsByYear W15676711452020 @default.
• W1567671145 countsByYear W15676711452022 @default.
• W1567671145 countsByYear W15676711452023 @default.
• W1567671145 crossrefType "journal-article" @default.
• W1567671145 hasAuthorship W1567671145A5003370819 @default.
• W1567671145 hasAuthorship W1567671145A5004959719 @default.
• W1567671145 hasAuthorship W1567671145A5010000360 @default.
• W1567671145 hasAuthorship W1567671145A5026564126 @default.
• W1567671145 hasAuthorship W1567671145A5051404866 @default.
• W1567671145 hasAuthorship W1567671145A5060032203 @default.
• W1567671145 hasAuthorship W1567671145A5064462389 @default.
• W1567671145 hasAuthorship W1567671145A5073081812 @default.
• W1567671145 hasAuthorship W1567671145A5080357880 @default.
• W1567671145 hasBestOaLocation W15676711451 @default.
• W1567671145 hasConcept C118552586 @default.
• W1567671145 hasConcept C126322002 @default.
• W1567671145 hasConcept C134018914 @default.
• W1567671145 hasConcept C15744967 @default.
• W1567671145 hasConcept C159654299 @default.
• W1567671145 hasConcept C170493617 @default.
• W1567671145 hasConcept C203014093 @default.
• W1567671145 hasConcept C2775864247 @default.
• W1567671145 hasConcept C2777529043 @default.
• W1567671145 hasConcept C2780712732 @default.
• W1567671145 hasConcept C38042653 @default.
• W1567671145 hasConcept C53910766 @default.
• W1567671145 hasConcept C558461103 @default.
• W1567671145 hasConcept C71924100 @default.
• W1567671145 hasConcept C8891405 @default.
• W1567671145 hasConceptScore W1567671145C118552586 @default.
• W1567671145 hasConceptScore W1567671145C126322002 @default.
• W1567671145 hasConceptScore W1567671145C134018914 @default.
• W1567671145 hasConceptScore W1567671145C15744967 @default.
• W1567671145 hasConceptScore W1567671145C159654299 @default.
• W1567671145 hasConceptScore W1567671145C170493617 @default.
• W1567671145 hasConceptScore W1567671145C203014093 @default.
• W1567671145 hasConceptScore W1567671145C2775864247 @default.
• W1567671145 hasConceptScore W1567671145C2777529043 @default.
• W1567671145 hasConceptScore W1567671145C2780712732 @default.
• W1567671145 hasConceptScore W1567671145C38042653 @default.
• W1567671145 hasConceptScore W1567671145C53910766 @default.
• W1567671145 hasConceptScore W1567671145C558461103 @default.
• W1567671145 hasConceptScore W1567671145C71924100 @default.
• W1567671145 hasConceptScore W1567671145C8891405 @default.
• W1567671145 hasIssue "4" @default.
• W1567671145 hasLocation W15676711451 @default.
• W1567671145 hasLocation W15676711452 @default.
• W1567671145 hasOpenAccess W1567671145 @default.
• W1567671145 hasPrimaryLocation W15676711451 @default.
• W1567671145 hasRelatedWork W1522849455 @default.
• W1567671145 hasRelatedWork W2027411819 @default.
• W1567671145 hasRelatedWork W2027622212 @default.
• W1567671145 hasRelatedWork W2050824222 @default.
• W1567671145 hasRelatedWork W2055572014 @default.
• W1567671145 hasRelatedWork W2056234617 @default.
• W1567671145 hasRelatedWork W2107899720 @default.
• W1567671145 hasRelatedWork W2128286595 @default.
• W1567671145 hasRelatedWork W2748952813 @default.
• W1567671145 hasRelatedWork W4241062279 @default.

• next