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- W1567676800 abstract "Abstract Activation-induced cell death is a process by which overactivated T cells are eliminated, thus preventing potential autoimmune attacks. Two known mediators of activation-induced cell death are Fas(CD95) ligand (FasL) and APO2 ligand (APO2L)/TNF-related apoptosis-inducing ligand (TRAIL). We show here that upon mitogenic stimulation, bioactive FasL and APO2L are released from the T cell leukemia Jurkat and from normal human T cell blasts as intact, nonproteolyzed proteins associated with a particulate, ultracentrifugable fraction. We have characterized this fraction as microvesicles of 100–200 nm in diameter. These microvesicles are released from Jurkat and T cell blasts shortly (≤1 h) after PHA stimulation, well before the cell enters apoptosis. FasL- and APO2L-containing vesicles are also present in supernatants from PHA-activated fresh human PBMC. These observations provide the basis for a new and efficient mechanism for the rapid induction of autocrine or paracrine cell death during immune regulation." @default.
- W1567676800 created "2016-06-24" @default.
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- W1567676800 date "1999-08-01" @default.
- W1567676800 modified "2023-10-18" @default.
- W1567676800 title "Activated Human T Cells Release Bioactive Fas Ligand and APO2 Ligand in Microvesicles" @default.
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- W1567676800 doi "https://doi.org/10.4049/jimmunol.163.3.1274" @default.
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