FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567679063> ?p ?o ?g. }

• W1567679063 endingPage "785" @default.
• W1567679063 startingPage "781" @default.
• W1567679063 abstract "The aromatic amino acids are synthesized via a common biosynthetic pathway. A tryptophan-producing mutant of Corynebacterium glutamicum was genetically engineered to produce tyrosine or phenylalanine in abundance. To achieve this, three biosynthetic genes encoding the first enzyme in the common pathway, 3-deoxy- d - arabino -heptulosonate 7-phosphate synthase (DS), and the branch-point enzymes chorismate mutase and prephenate dehydratase were individually cloned from regulatory mutants of C. glutamicum which have either of the corresponding enzymes desensitized to end product inhibition. These cloned genes were assembled one after another onto a multicopy vector of C. glutamicum to yield two recombinant plasmids. One plasmid, designated pKY1, contains the DS and chorismate mutase genes, and the other, designated pKF1, contains all three biosynthetic genes. The enzymes specified by both plasmids were simultaneously overexpressed approximately sevenfold relative to the chromosomally encoded enzymes in a C. glutamicum strain. When transformed with pKY1 or pKF1, tryptophan-producing C. glutamicum KY10865, with the ability to produce 18 g of tryptophan per liter, was altered to produce a large amount of tyrosine (26 g/liter) or phenylalanine (28 g/liter), respectively, because the accelerated carbon flow through the common pathway was redirected to tyrosine or phenylalanine." @default.
• W1567679063 created "2016-06-24" @default.
• W1567679063 creator A5020262927 @default.
• W1567679063 creator A5020615740 @default.
• W1567679063 date "1992-03-01" @default.
• W1567679063 modified "2023-09-27" @default.
• W1567679063 title "Metabolic Engineering To Produce Tyrosine or Phenylalanine in a Tryptophan-Producing <i>Corynebacterium glutamicum</i> Strain" @default.
• W1567679063 cites W1485848229 @default.
• W1567679063 cites W1549182485 @default.
• W1567679063 cites W1601687245 @default.
• W1567679063 cites W1626189152 @default.
• W1567679063 cites W1736642777 @default.
• W1567679063 cites W1754641653 @default.
• W1567679063 cites W1884643618 @default.
• W1567679063 cites W1926560488 @default.
• W1567679063 cites W1971392749 @default.
• W1567679063 cites W2010437243 @default.
• W1567679063 cites W2015402064 @default.
• W1567679063 cites W2017069314 @default.
• W1567679063 cites W2020061999 @default.
• W1567679063 cites W2021670102 @default.
• W1567679063 cites W2028558317 @default.
• W1567679063 cites W2113665730 @default.
• W1567679063 cites W2128635872 @default.
• W1567679063 cites W2138913088 @default.
• W1567679063 cites W2140296235 @default.
• W1567679063 cites W2144634347 @default.
• W1567679063 cites W2155612513 @default.
• W1567679063 cites W2172003650 @default.
• W1567679063 cites W2338368214 @default.
• W1567679063 cites W283401092 @default.
• W1567679063 doi "https://doi.org/10.1128/aem.58.3.781-785.1992" @default.
• W1567679063 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/195334" @default.
• W1567679063 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16348670" @default.
• W1567679063 hasPublicationYear "1992" @default.
• W1567679063 type Work @default.
• W1567679063 sameAs 1567679063 @default.
• W1567679063 citedByCount "109" @default.
• W1567679063 countsByYear W15676790632012 @default.
• W1567679063 countsByYear W15676790632013 @default.
• W1567679063 countsByYear W15676790632014 @default.
• W1567679063 countsByYear W15676790632015 @default.
• W1567679063 countsByYear W15676790632016 @default.
• W1567679063 countsByYear W15676790632017 @default.
• W1567679063 countsByYear W15676790632018 @default.
• W1567679063 countsByYear W15676790632019 @default.
• W1567679063 countsByYear W15676790632020 @default.
• W1567679063 countsByYear W15676790632021 @default.
• W1567679063 countsByYear W15676790632022 @default.
• W1567679063 countsByYear W15676790632023 @default.
• W1567679063 crossrefType "journal-article" @default.
• W1567679063 hasAuthorship W1567679063A5020262927 @default.
• W1567679063 hasAuthorship W1567679063A5020615740 @default.
• W1567679063 hasBestOaLocation W15676790631 @default.
• W1567679063 hasConcept C104317684 @default.
• W1567679063 hasConcept C181199279 @default.
• W1567679063 hasConcept C22744801 @default.
• W1567679063 hasConcept C2776165026 @default.
• W1567679063 hasConcept C2776260651 @default.
• W1567679063 hasConcept C2776706248 @default.
• W1567679063 hasConcept C2777431362 @default.
• W1567679063 hasConcept C2777992278 @default.
• W1567679063 hasConcept C2778526059 @default.
• W1567679063 hasConcept C515207424 @default.
• W1567679063 hasConcept C553450214 @default.
• W1567679063 hasConcept C55493867 @default.
• W1567679063 hasConcept C6350086 @default.
• W1567679063 hasConcept C86803240 @default.
• W1567679063 hasConceptScore W1567679063C104317684 @default.
• W1567679063 hasConceptScore W1567679063C181199279 @default.
• W1567679063 hasConceptScore W1567679063C22744801 @default.
• W1567679063 hasConceptScore W1567679063C2776165026 @default.
• W1567679063 hasConceptScore W1567679063C2776260651 @default.
• W1567679063 hasConceptScore W1567679063C2776706248 @default.
• W1567679063 hasConceptScore W1567679063C2777431362 @default.
• W1567679063 hasConceptScore W1567679063C2777992278 @default.
• W1567679063 hasConceptScore W1567679063C2778526059 @default.
• W1567679063 hasConceptScore W1567679063C515207424 @default.
• W1567679063 hasConceptScore W1567679063C553450214 @default.
• W1567679063 hasConceptScore W1567679063C55493867 @default.
• W1567679063 hasConceptScore W1567679063C6350086 @default.
• W1567679063 hasConceptScore W1567679063C86803240 @default.
• W1567679063 hasIssue "3" @default.
• W1567679063 hasLocation W15676790631 @default.
• W1567679063 hasLocation W15676790632 @default.
• W1567679063 hasLocation W15676790633 @default.
• W1567679063 hasOpenAccess W1567679063 @default.
• W1567679063 hasPrimaryLocation W15676790631 @default.
• W1567679063 hasRelatedWork W153327293 @default.
• W1567679063 hasRelatedWork W1567679063 @default.
• W1567679063 hasRelatedWork W1595063322 @default.
• W1567679063 hasRelatedWork W1637747684 @default.
• W1567679063 hasRelatedWork W1984725847 @default.
• W1567679063 hasRelatedWork W2022461097 @default.
• W1567679063 hasRelatedWork W2042040184 @default.
• W1567679063 hasRelatedWork W283401092 @default.
• W1567679063 hasRelatedWork W4239812013 @default.
• W1567679063 hasRelatedWork W848914235 @default.

• next