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- W1567679184 abstract "SIR, Transient acantholytic dermatosis (TAD) was originally described by Grover in 1970,1 as a pruritic, self‐limiting papular or papulovesicular eruption predominantly distributed on the trunk of white middle‐aged men. The histopathological hallmark of TAD is suprabasal acantholysis, occurring at different levels of the epidermis.2 TAD is of uncertain origin, with most cases related to sunlight, heat or sweating.1–5 We describe the first case of Grover’s disease secondary to ribavirin. A 55‐year‐old man with chronic active hepatitis C presented with a pruritic papular eruption on the trunk lasting for 2 weeks. Examination showed multiple erythematous and excoriated papules on the neck, trunk, upper arms and thighs (Fig. 1a). The lesions appeared 2 weeks after combination therapy with oral ribavirin 1 g daily and subcutaneous interferon alpha‐2b 3 MU twice weekly, prescribed for relapse of the hepatitis. Previously, he had been treated with interferon alpha alone at the same dosage for 7 months, and which had then been suspended for 4 months. Histopathological examination revealed epidermal spongiosis with vesicle formation and small foci of suprabasal acantholysis with occasional dyskeratotic cells, corps rounds and grains (Fig. 1b). With the suspension of ribavirin, the lesions gradually faded. Twelve days later, the drug was reintroduced at the initial dosage but after 1 week, an exacerbation of the clinical picture was noticed. All the medication taken by the patient was then suspended and he was treated with oral prednisolone 40 mg daily for 10 days, with complete resolution of the cutaneous lesions." @default.
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- W1567679184 date "2000-06-01" @default.
- W1567679184 modified "2023-10-10" @default.
- W1567679184 title "Grover’s disease secondary to ribavirin" @default.
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- W1567679184 doi "https://doi.org/10.1046/j.1365-2133.2000.03574.x" @default.
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