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• W1567686877 abstract "In species that are distributed across steep environmental gradients, adaptive variation in physiological performance may be attributable to transcriptional plasticity in underlying regulatory networks. Here we report the results of common-garden experiments that were designed to elucidate the role of regulatory plasticity in evolutionary adaptation to hypoxic cold-stress in deer mice (Peromyscus maniculatus). We integrated genomic transcriptional profiles with measures of metabolic enzyme activities and whole-animal thermogenic performance under hypoxia in highland (4350 m) and lowland (430 m) mice from three experimental groups: (1) wild-caught mice that were sampled at their native elevations; (2) wild-caught/lab-reared mice that were deacclimated to low-elevation conditions in a common-garden lab environment; and (3) the F(1) progeny of deacclimated mice that were maintained under the same low-elevation common-garden conditions. In each experimental group, highland mice exhibited greater thermogenic capacities than lowland mice, and this enhanced performance was associated with upregulation of transcriptional modules that influence several hierarchical steps in the O(2) cascade, including tissue O(2) diffusion (angiogenesis) and tissue O(2) utilization (metabolic fuel use and cellular oxidative capacity). Most of these performance-related transcriptomic changes occurred over physiological and developmental timescales, suggesting that regulatory plasticity makes important contributions to fitness-related physiological performance in highland deer mice." @default.
• W1567686877 created "2016-06-24" @default.
• W1567686877 creator A5026872382 @default.
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• W1567686877 creator A5052209534 @default.
• W1567686877 creator A5078032965 @default.
• W1567686877 date "2013-09-16" @default.
• W1567686877 modified "2023-09-30" @default.
• W1567686877 title "FUNCTIONAL GENOMICS OF ADAPTATION TO HYPOXIC COLD-STRESS IN HIGH-ALTITUDE DEER MICE: TRANSCRIPTOMIC PLASTICITY AND THERMOGENIC PERFORMANCE" @default.
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• W1567686877 doi "https://doi.org/10.1111/evo.12257" @default.
• W1567686877 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4399701" @default.
• W1567686877 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24102503" @default.
• W1567686877 hasPublicationYear "2013" @default.
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