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- W1567694658 abstract "This chapter focuses on the maturation of the immune response. The maturation of the immune system is considered to be a precisely controlled process, which results in a large number of highly differentiated cells, each committed to the production of a single (antibody). During prolonged exposure to an antigen, there is a progressive shift toward a cell population, which produces binding antibodies more tightly. The chapter discusses the organization of antibody genes and somatic diversification of germline. In response to a primary antigenic stimulus, B cells proliferate and differentiate. Some interact with stimulated T cells to give rise to T cell dependent responses, to affinity maturation, and to memory. Affinity maturation is primarily dependent on mutations in the antibody genes and selection of those that express improved antigen binding properties. Selected cells give rise to terminally differentiated plasma cells, actively secreting antibody, and to memory cells. The chapter also summarizes many of the features of hypermutation that have been deduced from the sequence analysis of mutated V genes. The affinity maturation is the result of complementary diversification, which is not generated by the primary repertoire but is required to increase the number of contact residues or the fine geometry of a binding site selected to bind defined antigens. This chapter proposes that evolution has favored high-mutation-rate DNA configurations (intrinsic hot spots) in CDR segments designed to complement the diversity generated by germline and combinatorial diversity." @default.
- W1567694658 created "2016-06-24" @default.
- W1567694658 creator A5018578853 @default.
- W1567694658 creator A5063804278 @default.
- W1567694658 date "1996-01-01" @default.
- W1567694658 modified "2023-09-26" @default.
- W1567694658 title "Maturation of the Immune Response" @default.
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