Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567709725> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W1567709725 endingPage "3390" @default.
- W1567709725 startingPage "3387" @default.
- W1567709725 abstract "Enzymatic cleavage of sialic acid from human blood clotting factor IX results in a loss of factor IX clotting activity. The loss of clotting activity and the rate of release of sialic acid follow the same time courses. Control experiments have ruled out several explanations for the loss of factor IX activity: proteolytic degradation, inhibitory effects of free sialic acid, and non-specific inhibition of the clotting assays. Furthermore, no inhibition was seen when similar enzymatic cleavage was carried out on factor X and factor VIII. Therefore, we suggest that the loss of factor IX activity is the direct result of cleavage of sialic acid from the protein. Most of the inhibition appeared to be an effect on the activity of factor IXa itself, and thus far, little or no effect has been shown on the activation of factor IX to IXa. The structural basis for this unusual effect of sialic acid on protein function currently is being investigated." @default.
- W1567709725 created "2016-06-24" @default.
- W1567709725 creator A5020761710 @default.
- W1567709725 creator A5027851589 @default.
- W1567709725 date "1984-03-01" @default.
- W1567709725 modified "2023-09-29" @default.
- W1567709725 title "Blood clotting factor IX. Loss of activity after cleavage of sialic acid residues." @default.
- W1567709725 cites W1580023435 @default.
- W1567709725 cites W1585764350 @default.
- W1567709725 cites W1942443265 @default.
- W1567709725 cites W1965293723 @default.
- W1567709725 cites W1967882894 @default.
- W1567709725 cites W1971784860 @default.
- W1567709725 cites W1996439365 @default.
- W1567709725 cites W1999427098 @default.
- W1567709725 cites W2010814176 @default.
- W1567709725 cites W2015152673 @default.
- W1567709725 cites W2019435196 @default.
- W1567709725 cites W2020221662 @default.
- W1567709725 cites W2021331922 @default.
- W1567709725 cites W2069254375 @default.
- W1567709725 cites W2077806825 @default.
- W1567709725 cites W2088940155 @default.
- W1567709725 cites W2100837269 @default.
- W1567709725 cites W2413474811 @default.
- W1567709725 cites W2414305949 @default.
- W1567709725 cites W2462030978 @default.
- W1567709725 doi "https://doi.org/10.1016/s0021-9258(17)43103-6" @default.
- W1567709725 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6323421" @default.
- W1567709725 hasPublicationYear "1984" @default.
- W1567709725 type Work @default.
- W1567709725 sameAs 1567709725 @default.
- W1567709725 citedByCount "35" @default.
- W1567709725 countsByYear W15677097252014 @default.
- W1567709725 crossrefType "journal-article" @default.
- W1567709725 hasAuthorship W1567709725A5020761710 @default.
- W1567709725 hasAuthorship W1567709725A5027851589 @default.
- W1567709725 hasBestOaLocation W15677097251 @default.
- W1567709725 hasConcept C126322002 @default.
- W1567709725 hasConcept C151730666 @default.
- W1567709725 hasConcept C175156509 @default.
- W1567709725 hasConcept C185592680 @default.
- W1567709725 hasConcept C2778382381 @default.
- W1567709725 hasConcept C2778671442 @default.
- W1567709725 hasConcept C2780115458 @default.
- W1567709725 hasConcept C2781221834 @default.
- W1567709725 hasConcept C2910877098 @default.
- W1567709725 hasConcept C2992139802 @default.
- W1567709725 hasConcept C2992598832 @default.
- W1567709725 hasConcept C43369102 @default.
- W1567709725 hasConcept C55493867 @default.
- W1567709725 hasConcept C71924100 @default.
- W1567709725 hasConcept C86803240 @default.
- W1567709725 hasConceptScore W1567709725C126322002 @default.
- W1567709725 hasConceptScore W1567709725C151730666 @default.
- W1567709725 hasConceptScore W1567709725C175156509 @default.
- W1567709725 hasConceptScore W1567709725C185592680 @default.
- W1567709725 hasConceptScore W1567709725C2778382381 @default.
- W1567709725 hasConceptScore W1567709725C2778671442 @default.
- W1567709725 hasConceptScore W1567709725C2780115458 @default.
- W1567709725 hasConceptScore W1567709725C2781221834 @default.
- W1567709725 hasConceptScore W1567709725C2910877098 @default.
- W1567709725 hasConceptScore W1567709725C2992139802 @default.
- W1567709725 hasConceptScore W1567709725C2992598832 @default.
- W1567709725 hasConceptScore W1567709725C43369102 @default.
- W1567709725 hasConceptScore W1567709725C55493867 @default.
- W1567709725 hasConceptScore W1567709725C71924100 @default.
- W1567709725 hasConceptScore W1567709725C86803240 @default.
- W1567709725 hasIssue "6" @default.
- W1567709725 hasLocation W15677097251 @default.
- W1567709725 hasOpenAccess W1567709725 @default.
- W1567709725 hasPrimaryLocation W15677097251 @default.
- W1567709725 hasRelatedWork W1567709725 @default.
- W1567709725 hasRelatedWork W1595004840 @default.
- W1567709725 hasRelatedWork W173472931 @default.
- W1567709725 hasRelatedWork W1998843541 @default.
- W1567709725 hasRelatedWork W2058269227 @default.
- W1567709725 hasRelatedWork W2343399448 @default.
- W1567709725 hasRelatedWork W2419438366 @default.
- W1567709725 hasRelatedWork W2463207153 @default.
- W1567709725 hasRelatedWork W2942665946 @default.
- W1567709725 hasRelatedWork W3118915307 @default.
- W1567709725 hasVolume "259" @default.
- W1567709725 isParatext "false" @default.
- W1567709725 isRetracted "false" @default.
- W1567709725 magId "1567709725" @default.
- W1567709725 workType "article" @default.