FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567722304> ?p ?o ?g. }

• W1567722304 abstract "Osteolytic bone disease in multiple myeloma (MM) is a common event. Already at diagnosis, approximately eighty percent of patients present with abnormal bone structure [1;2]. During disease progression a large proportion of patients will develop ostelytic lesions [3]. MM bone disease not only results in a reduced quality of life due to pain, pathological fractures, or symptomatic hypercalcaemia [4]; but may also be the deciding factor that determines if a patient requires anti-myeloma treatment or if a watch and wait strategy can be applied [5]. In this chapter we will discuss the normal bone remodelling process, and how it is affected in MM. During the last decades, increased knowledge about bone pathophysiology in general has led to an improved understanding of MM bone disease. The description of the receptor activator of nuclear factor kappa B (RANK) and its ligand in the nineties was one of the most significant steps. We will also address how biochemical markers may be used to monitor the velocity of the different processes in bone remodelling. The next part of the chapter will be dedicated to the treatment of MM bone disease. For many years, bisphosphonates have been a cornerstone in the treatment of MM bone disease and despite the occurrence of osteonecrosis of the jaw that was first report‐ ed as a result of the of bisphosphonate treatment in the early part of this century, these agents remain the most important components of treatment for MM bone disease. Lastly, we will discuss how various anti-myeloma treatments may influence bone turnover. During the last decade a number of novel drugs have been approved for the treatment of MM and especially proteasome inhibitors seems to have a positive effect on MM bone disease besides their anti-myleoma effect." @default.
• W1567722304 created "2016-06-24" @default.
• W1567722304 creator A5028707750 @default.
• W1567722304 creator A5043515311 @default.
• W1567722304 creator A5049717703 @default.
• W1567722304 creator A5076872867 @default.
• W1567722304 date "2013-04-10" @default.
• W1567722304 modified "2023-09-30" @default.
• W1567722304 title "Bone Disease in Multiple Myeloma" @default.
• W1567722304 cites W1502352305 @default.
• W1567722304 cites W1582684482 @default.
• W1567722304 cites W1583650818 @default.
• W1567722304 cites W182772309 @default.
• W1567722304 cites W1839671168 @default.
• W1567722304 cites W1842497498 @default.
• W1567722304 cites W1899376469 @default.
• W1567722304 cites W1932993947 @default.
• W1567722304 cites W1958364130 @default.
• W1567722304 cites W1964251055 @default.
• W1567722304 cites W1966397617 @default.
• W1567722304 cites W1968326919 @default.
• W1567722304 cites W1973328408 @default.
• W1567722304 cites W1978887839 @default.
• W1567722304 cites W1981560703 @default.
• W1567722304 cites W1982660528 @default.
• W1567722304 cites W1983807890 @default.
• W1567722304 cites W1984068295 @default.
• W1567722304 cites W1986580482 @default.
• W1567722304 cites W1989343687 @default.
• W1567722304 cites W1991636458 @default.
• W1567722304 cites W1992422220 @default.
• W1567722304 cites W1993479864 @default.
• W1567722304 cites W1995238317 @default.
• W1567722304 cites W1998854709 @default.
• W1567722304 cites W1999077925 @default.
• W1567722304 cites W1999352200 @default.
• W1567722304 cites W2000096438 @default.
• W1567722304 cites W2002918019 @default.
• W1567722304 cites W2005603603 @default.
• W1567722304 cites W2006671411 @default.
• W1567722304 cites W2012448313 @default.
• W1567722304 cites W2012582974 @default.
• W1567722304 cites W2013931313 @default.
• W1567722304 cites W2014887548 @default.
• W1567722304 cites W2015377018 @default.
• W1567722304 cites W2022292514 @default.
• W1567722304 cites W2025672294 @default.
• W1567722304 cites W2025707250 @default.
• W1567722304 cites W2031883266 @default.
• W1567722304 cites W2035237112 @default.
• W1567722304 cites W2036026045 @default.
• W1567722304 cites W2038329170 @default.
• W1567722304 cites W2039215669 @default.
• W1567722304 cites W2043295936 @default.
• W1567722304 cites W2044835347 @default.
• W1567722304 cites W2047266867 @default.
• W1567722304 cites W2048709843 @default.
• W1567722304 cites W2049848179 @default.
• W1567722304 cites W2051019115 @default.
• W1567722304 cites W2053441492 @default.
• W1567722304 cites W2053508383 @default.
• W1567722304 cites W2055966182 @default.
• W1567722304 cites W2057120263 @default.
• W1567722304 cites W2063392511 @default.
• W1567722304 cites W2066000727 @default.
• W1567722304 cites W2066329342 @default.
• W1567722304 cites W2066639236 @default.
• W1567722304 cites W2068819080 @default.
• W1567722304 cites W2070671065 @default.
• W1567722304 cites W2072797307 @default.
• W1567722304 cites W2075356469 @default.
• W1567722304 cites W2077015738 @default.
• W1567722304 cites W2078493291 @default.
• W1567722304 cites W2078671054 @default.
• W1567722304 cites W2082870980 @default.
• W1567722304 cites W2093252878 @default.
• W1567722304 cites W2093741838 @default.
• W1567722304 cites W2093757149 @default.
• W1567722304 cites W2095098163 @default.
• W1567722304 cites W2095109341 @default.
• W1567722304 cites W2095255742 @default.
• W1567722304 cites W2097878023 @default.
• W1567722304 cites W2099281806 @default.
• W1567722304 cites W2103011422 @default.
• W1567722304 cites W2105459402 @default.
• W1567722304 cites W2107208293 @default.
• W1567722304 cites W2108595411 @default.
• W1567722304 cites W2109591324 @default.
• W1567722304 cites W2112413552 @default.
• W1567722304 cites W2115871403 @default.
• W1567722304 cites W2117800069 @default.
• W1567722304 cites W2119440553 @default.
• W1567722304 cites W2119486128 @default.
• W1567722304 cites W2119801904 @default.
• W1567722304 cites W2122720369 @default.
• W1567722304 cites W2122972229 @default.
• W1567722304 cites W2125707659 @default.
• W1567722304 cites W2126347015 @default.
• W1567722304 cites W2127909824 @default.
• W1567722304 cites W2128843508 @default.

• next