FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567722540> ?p ?o ?g. }

• W1567722540 endingPage "78" @default.
• W1567722540 startingPage "62" @default.
• W1567722540 abstract "Transplantation of an organ, tissue, or cells from an allogeneic donor triggers a dialogue between the innate and adaptive immune systems that results in a cascade of mechanisms that not only initiate, but also direct the destruction of the transplant if they are allowed to run their full course. At the same time, but at a slower pace, mechanisms that can regulate or control these same immune responses are established. Unfortunately, in the case of transplantation, without active intervention the natural mechanisms of immune regulation are established too slowly and are not powerful enough to prevent rejection. Nevertheless, these fail-safe mechanisms that are built into every immune response are essential to ensure that each immune response an individual makes is appropriate to the context in which it is triggered. Immune responses that are too weak will not, in the case of an infection, clear the infectious agents, thereby threatening the survival of the host. In contrast, immune responses that are too vigorous have the potential to cause damage to the host ’ s own tissues, again potentially compromising the host ’ s wellbeing. The immune system, therefore, strives to make an appropriate, measured response that is sufficient to eliminate the antigen that triggered it, but not so vigorous that long-lasting tissue damage is caused. In the case of transplantation, the immune response that elicits rejection or destruction of allogeneic transplanted cells or tissues is arguably at the more vigorous end of the spectrum. Importantly, experimental data are demonstrating that the natural mechanisms of control/regulation that are triggered during an alloimmune response can be harnessed to control the response and prevent rejection, especially when immunotherapy that supports immune regulation is used." @default.
• W1567722540 created "2016-06-24" @default.
• W1567722540 creator A5050506872 @default.
• W1567722540 creator A5069765168 @default.
• W1567722540 date "2010-04-16" @default.
• W1567722540 modified "2023-09-25" @default.
• W1567722540 title "Regulation of the Alloimmune Response" @default.
• W1567722540 cites W1481580670 @default.
• W1567722540 cites W1494573187 @default.
• W1567722540 cites W1509909867 @default.
• W1567722540 cites W1518759830 @default.
• W1567722540 cites W1539591812 @default.
• W1567722540 cites W1563336787 @default.
• W1567722540 cites W1581904411 @default.
• W1567722540 cites W1587249246 @default.
• W1567722540 cites W1588569931 @default.
• W1567722540 cites W1593238885 @default.
• W1567722540 cites W1862437987 @default.
• W1567722540 cites W1893566975 @default.
• W1567722540 cites W1919714885 @default.
• W1567722540 cites W1947199545 @default.
• W1567722540 cites W1966621240 @default.
• W1567722540 cites W1966832454 @default.
• W1567722540 cites W1967056047 @default.
• W1567722540 cites W1967702267 @default.
• W1567722540 cites W1969797237 @default.
• W1567722540 cites W1970586342 @default.
• W1567722540 cites W1972544648 @default.
• W1567722540 cites W1972758309 @default.
• W1567722540 cites W1974381902 @default.
• W1567722540 cites W1976702412 @default.
• W1567722540 cites W1978373343 @default.
• W1567722540 cites W1979878166 @default.
• W1567722540 cites W1982006380 @default.
• W1567722540 cites W1982451837 @default.
• W1567722540 cites W1983019708 @default.
• W1567722540 cites W1987128447 @default.
• W1567722540 cites W1988497921 @default.
• W1567722540 cites W1989091670 @default.
• W1567722540 cites W1990620586 @default.
• W1567722540 cites W1991209884 @default.
• W1567722540 cites W1993669291 @default.
• W1567722540 cites W1997201294 @default.
• W1567722540 cites W2006561389 @default.
• W1567722540 cites W2007362831 @default.
• W1567722540 cites W2008686731 @default.
• W1567722540 cites W2009487870 @default.
• W1567722540 cites W2015085911 @default.
• W1567722540 cites W2016345107 @default.
• W1567722540 cites W2016594112 @default.
• W1567722540 cites W2021428880 @default.
• W1567722540 cites W2022022565 @default.
• W1567722540 cites W2022174161 @default.
• W1567722540 cites W2022283661 @default.
• W1567722540 cites W2022339431 @default.
• W1567722540 cites W2025446247 @default.
• W1567722540 cites W2033801220 @default.
• W1567722540 cites W2034430001 @default.
• W1567722540 cites W2034643457 @default.
• W1567722540 cites W2039175257 @default.
• W1567722540 cites W2039521561 @default.
• W1567722540 cites W2041416134 @default.
• W1567722540 cites W2042117545 @default.
• W1567722540 cites W2048073154 @default.
• W1567722540 cites W2051683789 @default.
• W1567722540 cites W2051972593 @default.
• W1567722540 cites W2056207471 @default.
• W1567722540 cites W2057793002 @default.
• W1567722540 cites W2061393519 @default.
• W1567722540 cites W2068639447 @default.
• W1567722540 cites W2070247501 @default.
• W1567722540 cites W2070461635 @default.
• W1567722540 cites W2071282292 @default.
• W1567722540 cites W2071869204 @default.
• W1567722540 cites W2072189851 @default.
• W1567722540 cites W2072538780 @default.
• W1567722540 cites W2074205101 @default.
• W1567722540 cites W2075097399 @default.
• W1567722540 cites W2075420367 @default.
• W1567722540 cites W2076000587 @default.
• W1567722540 cites W2076899204 @default.
• W1567722540 cites W2085918020 @default.
• W1567722540 cites W2086516001 @default.
• W1567722540 cites W2089327657 @default.
• W1567722540 cites W2089641632 @default.
• W1567722540 cites W2093011834 @default.
• W1567722540 cites W2097937083 @default.
• W1567722540 cites W2104049583 @default.
• W1567722540 cites W2104959557 @default.
• W1567722540 cites W2106190040 @default.
• W1567722540 cites W2106756221 @default.
• W1567722540 cites W2108860192 @default.
• W1567722540 cites W2110176131 @default.
• W1567722540 cites W2114412297 @default.
• W1567722540 cites W2116706483 @default.
• W1567722540 cites W2118994799 @default.
• W1567722540 cites W2126845096 @default.
• W1567722540 cites W2131678280 @default.

• next