FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567731029> ?p ?o ?g. }

• W1567731029 endingPage "8434" @default.
• W1567731029 startingPage "8425" @default.
• W1567731029 abstract "Abstract To investigate the evolution and immune function of C-type lectin in amphioxus, the primitive representative of the chordate phylum, we identified three C-type lectins consisting solely of a carbohydrate recognition domain and N-terminal signal peptide and found that they had distinct express patterns in special tissues and immune response to stimulations analyzed by quantitative real-time PCR. We characterized the biochemical and biological properties of AmphiCTL1, which was dramatically up-regulated in amphioxus challenged with Staphylococcus aureus, Saccharomyces cerevisiae, and zymosan. Immunohistochemistry demonstrated that the localization of AmphiCTL1 protein was exclusively detected in the inner folding tissues of the hepatic diverticulum. Recombinant AmphiCTL1 was characterized as a typical Ca2+-dependent carbohydrate-binding protein possessing hemagglutinating activity, preferentially bound to all examined four Gram-positive bacteria and two yeast strains, but had little binding activity toward four Gram-negative bacteria we tested. It aggregated S. aureus and S. cerevisiae in a Ca2+-dependent manner and specifically bound to insoluble peptidoglycan and glucan, but not to LPS, lipoteichoic acid, and mannan. Calcium increased the intensity of the interaction between AmphiCTL1 and those components, but was not essential. This lectin directly killed S. aureus and S. cerevisiae in a Ca2+-independent fashion, and its binding to microorganism cell wall polysaccharides such as peptidoglycan and glucan preceded microbial killing activity. These findings suggested that AmphiCTL1 acted as a direct microbial killing C-type lectin through binding microbial targets via interaction with peptidoglycan and glucan. Thus, AmphiCTL1 may be an evolutionarily primitive form of antimicrobial protein involved in lectin-mediated innate immunity." @default.
• W1567731029 created "2016-06-24" @default.
• W1567731029 creator A5003484275 @default.
• W1567731029 creator A5003738856 @default.
• W1567731029 creator A5014845550 @default.
• W1567731029 creator A5032405545 @default.
• W1567731029 creator A5037792242 @default.
• W1567731029 creator A5044416428 @default.
• W1567731029 creator A5045270484 @default.
• W1567731029 creator A5052103443 @default.
• W1567731029 creator A5052548451 @default.
• W1567731029 creator A5065814437 @default.
• W1567731029 creator A5069992969 @default.
• W1567731029 creator A5088264016 @default.
• W1567731029 date "2007-12-15" @default.
• W1567731029 modified "2023-09-29" @default.
• W1567731029 title "A Short-Form C-Type Lectin from Amphioxus Acts as a Direct Microbial Killing Protein via Interaction with Peptidoglycan and Glucan" @default.
• W1567731029 cites W1561255328 @default.
• W1567731029 cites W1562268146 @default.
• W1567731029 cites W1964398101 @default.
• W1567731029 cites W1978537749 @default.
• W1567731029 cites W1982523330 @default.
• W1567731029 cites W1983497821 @default.
• W1567731029 cites W1986908601 @default.
• W1567731029 cites W1987050309 @default.
• W1567731029 cites W1991369439 @default.
• W1567731029 cites W2007984372 @default.
• W1567731029 cites W2010247691 @default.
• W1567731029 cites W2010980655 @default.
• W1567731029 cites W2030458862 @default.
• W1567731029 cites W2042562014 @default.
• W1567731029 cites W2053470258 @default.
• W1567731029 cites W2057250287 @default.
• W1567731029 cites W2084435672 @default.
• W1567731029 cites W2085136523 @default.
• W1567731029 cites W2085188889 @default.
• W1567731029 cites W2091080027 @default.
• W1567731029 cites W2093329141 @default.
• W1567731029 cites W2104063702 @default.
• W1567731029 cites W2120095412 @default.
• W1567731029 cites W2121783932 @default.
• W1567731029 cites W2131153334 @default.
• W1567731029 cites W2135649725 @default.
• W1567731029 cites W2139959938 @default.
• W1567731029 cites W2162562269 @default.
• W1567731029 cites W2282657502 @default.
• W1567731029 cites W2404509628 @default.
• W1567731029 doi "https://doi.org/10.4049/jimmunol.179.12.8425" @default.
• W1567731029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18056389" @default.
• W1567731029 hasPublicationYear "2007" @default.
• W1567731029 type Work @default.
• W1567731029 sameAs 1567731029 @default.
• W1567731029 citedByCount "158" @default.
• W1567731029 countsByYear W15677310292012 @default.
• W1567731029 countsByYear W15677310292013 @default.
• W1567731029 countsByYear W15677310292014 @default.
• W1567731029 countsByYear W15677310292015 @default.
• W1567731029 countsByYear W15677310292016 @default.
• W1567731029 countsByYear W15677310292017 @default.
• W1567731029 countsByYear W15677310292018 @default.
• W1567731029 countsByYear W15677310292019 @default.
• W1567731029 countsByYear W15677310292020 @default.
• W1567731029 countsByYear W15677310292021 @default.
• W1567731029 countsByYear W15677310292022 @default.
• W1567731029 countsByYear W15677310292023 @default.
• W1567731029 crossrefType "journal-article" @default.
• W1567731029 hasAuthorship W1567731029A5003484275 @default.
• W1567731029 hasAuthorship W1567731029A5003738856 @default.
• W1567731029 hasAuthorship W1567731029A5014845550 @default.
• W1567731029 hasAuthorship W1567731029A5032405545 @default.
• W1567731029 hasAuthorship W1567731029A5037792242 @default.
• W1567731029 hasAuthorship W1567731029A5044416428 @default.
• W1567731029 hasAuthorship W1567731029A5045270484 @default.
• W1567731029 hasAuthorship W1567731029A5052103443 @default.
• W1567731029 hasAuthorship W1567731029A5052548451 @default.
• W1567731029 hasAuthorship W1567731029A5065814437 @default.
• W1567731029 hasAuthorship W1567731029A5069992969 @default.
• W1567731029 hasAuthorship W1567731029A5088264016 @default.
• W1567731029 hasBestOaLocation W15677310291 @default.
• W1567731029 hasConcept C100817775 @default.
• W1567731029 hasConcept C106257327 @default.
• W1567731029 hasConcept C125235067 @default.
• W1567731029 hasConcept C2776123893 @default.
• W1567731029 hasConcept C2776634448 @default.
• W1567731029 hasConcept C2777576037 @default.
• W1567731029 hasConcept C2779222958 @default.
• W1567731029 hasConcept C2779489039 @default.
• W1567731029 hasConcept C2779719659 @default.
• W1567731029 hasConcept C2780758401 @default.
• W1567731029 hasConcept C523546767 @default.
• W1567731029 hasConcept C54355233 @default.
• W1567731029 hasConcept C55493867 @default.
• W1567731029 hasConcept C6977687 @default.
• W1567731029 hasConcept C86803240 @default.
• W1567731029 hasConcept C89423630 @default.
• W1567731029 hasConceptScore W1567731029C100817775 @default.
• W1567731029 hasConceptScore W1567731029C106257327 @default.
• W1567731029 hasConceptScore W1567731029C125235067 @default.

• next