Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567740502> ?p ?o ?g. }
- W1567740502 endingPage "1998" @default.
- W1567740502 startingPage "1985" @default.
- W1567740502 abstract "Abstract The biogenic amine serotonin (5‐HT) plays a key role in the regulation and modulation of many physiological and behavioural processes in both vertebrates and invertebrates. These functions are mediated through the binding of serotonin to its receptors, of which 13 subtypes have been characterized in vertebrates. We have isolated a cDNA from the honeybee Apis mellifera (Am 5‐ht 7) sharing high similarity to members of the 5‐HT 7 receptor family. Expression of the Am5‐HT 7 receptor in HEK293 cells results in an increase in basal cAMP levels, suggesting that Am5‐HT 7 is expressed as a constitutively active receptor. Serotonin application to Am 5‐ht7 ‐transfected cells elevates cyclic adenosine 3′,5′‐monophosphate (cAMP) levels in a dose‐dependent manner (EC 50 = 1.1–1.8 n m ). The Am5‐HT 7 receptor is also activated by 5‐carboxamidotryptamine, whereas methiothepin acts as an inverse agonist. Receptor expression has been investigated by RT‐PCR, in situ hybridization, and western blotting experiments. Receptor mRNA is expressed in the perikarya of various brain neuropils, including intrinsic mushroom body neurons, and in peripheral organs. This study marks the first comprehensive characterization of a serotonin receptor in the honeybee and should facilitate further analysis of the role(s) of the receptor in mediating the various central and peripheral effects of 5‐HT." @default.
- W1567740502 created "2016-06-24" @default.
- W1567740502 creator A5021753912 @default.
- W1567740502 creator A5033872155 @default.
- W1567740502 creator A5067411991 @default.
- W1567740502 creator A5079455167 @default.
- W1567740502 date "2006-07-10" @default.
- W1567740502 modified "2023-10-16" @default.
- W1567740502 title "Am5-HT7: molecular and pharmacological characterization of the first serotonin receptor of the honeybee (Apis mellifera)" @default.
- W1567740502 cites W1537334512 @default.
- W1567740502 cites W1540340052 @default.
- W1567740502 cites W1564515009 @default.
- W1567740502 cites W1565257873 @default.
- W1567740502 cites W1614960091 @default.
- W1567740502 cites W1649477831 @default.
- W1567740502 cites W1664200544 @default.
- W1567740502 cites W1689798268 @default.
- W1567740502 cites W1756891078 @default.
- W1567740502 cites W1779400460 @default.
- W1567740502 cites W1845007212 @default.
- W1567740502 cites W1953663624 @default.
- W1567740502 cites W1954929088 @default.
- W1567740502 cites W1972444757 @default.
- W1567740502 cites W1973756587 @default.
- W1567740502 cites W1975290466 @default.
- W1567740502 cites W1983912908 @default.
- W1567740502 cites W1985087585 @default.
- W1567740502 cites W1986742054 @default.
- W1567740502 cites W1987704449 @default.
- W1567740502 cites W1991426892 @default.
- W1567740502 cites W1994745653 @default.
- W1567740502 cites W2001213757 @default.
- W1567740502 cites W2006668156 @default.
- W1567740502 cites W2009105413 @default.
- W1567740502 cites W2011077323 @default.
- W1567740502 cites W2011393159 @default.
- W1567740502 cites W2012416906 @default.
- W1567740502 cites W2014001501 @default.
- W1567740502 cites W2016451134 @default.
- W1567740502 cites W2028336702 @default.
- W1567740502 cites W2030646640 @default.
- W1567740502 cites W2031719187 @default.
- W1567740502 cites W2032382791 @default.
- W1567740502 cites W2033067631 @default.
- W1567740502 cites W2034305089 @default.
- W1567740502 cites W2037491021 @default.
- W1567740502 cites W2043931575 @default.
- W1567740502 cites W2048054368 @default.
- W1567740502 cites W2054533142 @default.
- W1567740502 cites W2059126452 @default.
- W1567740502 cites W2064669765 @default.
- W1567740502 cites W2071728323 @default.
- W1567740502 cites W2075056702 @default.
- W1567740502 cites W2078926268 @default.
- W1567740502 cites W2079042711 @default.
- W1567740502 cites W2079882316 @default.
- W1567740502 cites W2080461836 @default.
- W1567740502 cites W2082551067 @default.
- W1567740502 cites W2082651629 @default.
- W1567740502 cites W2091629800 @default.
- W1567740502 cites W2097382368 @default.
- W1567740502 cites W2097745399 @default.
- W1567740502 cites W2099284593 @default.
- W1567740502 cites W2102438497 @default.
- W1567740502 cites W2102660603 @default.
- W1567740502 cites W2109227456 @default.
- W1567740502 cites W2110709054 @default.
- W1567740502 cites W2113638222 @default.
- W1567740502 cites W2122669559 @default.
- W1567740502 cites W2131086952 @default.
- W1567740502 cites W2154334152 @default.
- W1567740502 cites W2155270179 @default.
- W1567740502 cites W2158773116 @default.
- W1567740502 cites W2172531841 @default.
- W1567740502 cites W3009126244 @default.
- W1567740502 cites W4319308336 @default.
- W1567740502 cites W75664332 @default.
- W1567740502 doi "https://doi.org/10.1111/j.1471-4159.2006.04012.x" @default.
- W1567740502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16945110" @default.
- W1567740502 hasPublicationYear "2006" @default.
- W1567740502 type Work @default.
- W1567740502 sameAs 1567740502 @default.
- W1567740502 citedByCount "66" @default.
- W1567740502 countsByYear W15677405022012 @default.
- W1567740502 countsByYear W15677405022013 @default.
- W1567740502 countsByYear W15677405022014 @default.
- W1567740502 countsByYear W15677405022015 @default.
- W1567740502 countsByYear W15677405022016 @default.
- W1567740502 countsByYear W15677405022017 @default.
- W1567740502 countsByYear W15677405022018 @default.
- W1567740502 countsByYear W15677405022019 @default.
- W1567740502 countsByYear W15677405022020 @default.
- W1567740502 countsByYear W15677405022021 @default.
- W1567740502 countsByYear W15677405022022 @default.
- W1567740502 countsByYear W15677405022023 @default.
- W1567740502 crossrefType "journal-article" @default.
- W1567740502 hasAuthorship W1567740502A5021753912 @default.
- W1567740502 hasAuthorship W1567740502A5033872155 @default.