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- W1567744807 abstract "Publisher Summary Gene therapy seeks to alter or control the course of cellular action through the introduction of nucleic acids into a specific cell population. All gene therapy efforts to date in humans have been limited to somatic cells, such that the treatment is confined to the individual and not passed along to offspring. Gene therapy was initially conceived to treat inherited genetic disorders of a single gene, such as cystic fibrosis, adenosine deaminase deficiency associated with severe combined immunodeficiency (SCID), and hemophilia. For some conditions, the delivery of a gene encoding a protein that is pathologically absent can restore normal function. In other cases, suppression of a defective gene product may be the preferred course of action. Although several methods of gene therapy exist, the use of polymeric biomaterials for nonviral gene therapy has been a major area of focus in recent years. Methods have been developed for the controlled delivery of plasmid DNA from polymer nano- and microspheres as well as from tissue engineering scaffolds. Entrapment of DNA within polymeric carriers has been shown to enhance DNA stability, improve bioavailability, and promote cellular uptake. However, further investigation is warranted to improve the transfection efficiency and cell or tissue targeting." @default.
- W1567744807 created "2016-06-24" @default.
- W1567744807 creator A5012072492 @default.
- W1567744807 creator A5059620644 @default.
- W1567744807 date "2004-01-01" @default.
- W1567744807 modified "2023-09-26" @default.
- W1567744807 title "BIOMATERIALS AND GENE THERAPY" @default.
- W1567744807 cites W114135718 @default.
- W1567744807 cites W123802784 @default.
- W1567744807 cites W1482943240 @default.
- W1567744807 cites W1506102129 @default.
- W1567744807 cites W1511118087 @default.
- W1567744807 cites W1518166843 @default.
- W1567744807 cites W1520821663 @default.
- W1567744807 cites W1536781994 @default.
- W1567744807 cites W1549511377 @default.
- W1567744807 cites W1570307043 @default.
- W1567744807 cites W1579604458 @default.
- W1567744807 cites W1616824889 @default.
- W1567744807 cites W162668764 @default.
- W1567744807 cites W165015491 @default.
- W1567744807 cites W1681143022 @default.
- W1567744807 cites W182349513 @default.
- W1567744807 cites W1929043916 @default.
- W1567744807 cites W1964449683 @default.
- W1567744807 cites W1965181041 @default.
- W1567744807 cites W1966390198 @default.
- W1567744807 cites W1966782476 @default.
- W1567744807 cites W1967017841 @default.
- W1567744807 cites W1967377083 @default.
- W1567744807 cites W1969669184 @default.
- W1567744807 cites W1970812755 @default.
- W1567744807 cites W1971290197 @default.
- W1567744807 cites W1971613351 @default.
- W1567744807 cites W1978643345 @default.
- W1567744807 cites W1981401983 @default.
- W1567744807 cites W1986050278 @default.
- W1567744807 cites W1988289069 @default.
- W1567744807 cites W1989021197 @default.
- W1567744807 cites W1992156570 @default.
- W1567744807 cites W1992847347 @default.
- W1567744807 cites W1992909684 @default.
- W1567744807 cites W1995185323 @default.
- W1567744807 cites W1996545689 @default.
- W1567744807 cites W2002022916 @default.
- W1567744807 cites W2003291241 @default.
- W1567744807 cites W2003775503 @default.
- W1567744807 cites W2004451919 @default.
- W1567744807 cites W2004554125 @default.
- W1567744807 cites W2007926845 @default.
- W1567744807 cites W2009629825 @default.
- W1567744807 cites W2010655741 @default.
- W1567744807 cites W2010818956 @default.
- W1567744807 cites W2012329119 @default.
- W1567744807 cites W2013905916 @default.
- W1567744807 cites W2014488064 @default.
- W1567744807 cites W2014495927 @default.
- W1567744807 cites W2021169754 @default.
- W1567744807 cites W2021797033 @default.
- W1567744807 cites W2022434236 @default.
- W1567744807 cites W2023104469 @default.
- W1567744807 cites W2024332323 @default.
- W1567744807 cites W2026082338 @default.
- W1567744807 cites W2029566681 @default.
- W1567744807 cites W2029723752 @default.
- W1567744807 cites W2029882892 @default.
- W1567744807 cites W2031907367 @default.
- W1567744807 cites W2032307190 @default.
- W1567744807 cites W2034269897 @default.
- W1567744807 cites W2035319171 @default.
- W1567744807 cites W2036044902 @default.
- W1567744807 cites W2037215798 @default.
- W1567744807 cites W2038984754 @default.
- W1567744807 cites W2040282775 @default.
- W1567744807 cites W2041026285 @default.
- W1567744807 cites W2041153298 @default.
- W1567744807 cites W2042209155 @default.
- W1567744807 cites W2043764483 @default.
- W1567744807 cites W2044024064 @default.
- W1567744807 cites W2044693977 @default.
- W1567744807 cites W2045101135 @default.
- W1567744807 cites W2045787527 @default.
- W1567744807 cites W2051729665 @default.
- W1567744807 cites W2054023969 @default.
- W1567744807 cites W2055518942 @default.
- W1567744807 cites W2056831300 @default.
- W1567744807 cites W2057059824 @default.
- W1567744807 cites W2058916491 @default.
- W1567744807 cites W2061157968 @default.
- W1567744807 cites W2062062829 @default.
- W1567744807 cites W2063755160 @default.
- W1567744807 cites W2064143446 @default.
- W1567744807 cites W2064159705 @default.
- W1567744807 cites W2067749638 @default.
- W1567744807 cites W2068757603 @default.
- W1567744807 cites W2070426326 @default.
- W1567744807 cites W2072420774 @default.
- W1567744807 cites W2077934019 @default.