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- W1567750872 endingPage "317" @default.
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- W1567750872 abstract "Src family kinases (SFKs), in particular c-Src and c-Yes, are nonreceptor protein tyrosine kinases that mediate integrin signaling at focal adhesion complex at the cell-extracellular matrix interface to regulate cell adhesion, cell cycle progression, cell survival, proliferation and differentiation, most notably in cancer cells during tumorigenesis and metastasis. Interestingly, recent studies have shown that these two proto-oncogenes are integrated components of the stem cell niche and the cell-cell actin-based anchoring junction known as ectoplasmic specialization (ES) at the: (1) Sertoli cell-spermatid interface known as apical ES and (2) Sertoli-Sertoli cell interface known as basal ES which together with tight junctions (TJ), gap junctions and desmosomes constitute the blood-testis barrier (BTB). At the stem cell niche, these SFKs regulate spermatogonial stem cell (SSC) renewal to maintain the proper population of SSC/spermatogonia for spermatogenesis. At the apical ES and the BTB, c-Src and c-Yes confer cell adhesion either by maintaining the proper phosphorylation status of integral membrane proteins at the site which in turn regulates protein-protein interactions between integral membrane proteins and their adaptors, or by facilitating androgen action on spermatogenesis via a nongenomic pathway which also modulates cell adhesion in the seminiferous epithelium. Herein, we critically evaluate recent findings in the field regarding the roles of these two unlikely partners of spermatogenesis. We also propose a hypothetical model on the mechanistic functions of c-Src and c-Yes in spermatogenesis so that functional experiments can be designed in future studies." @default.
- W1567750872 created "2016-06-24" @default.
- W1567750872 creator A5033134672 @default.
- W1567750872 creator A5041273456 @default.
- W1567750872 creator A5050393987 @default.
- W1567750872 creator A5066071162 @default.
- W1567750872 date "2013-01-01" @default.
- W1567750872 modified "2023-09-24" @default.
- W1567750872 title "c-Src and c-Yes are Two Unlikely Partners of Spermatogenesis and their Roles in Blood-Testis Barrier Dynamics" @default.
- W1567750872 cites W1498374309 @default.
- W1567750872 cites W1517625476 @default.
- W1567750872 cites W1536452773 @default.
- W1567750872 cites W1600430222 @default.
- W1567750872 cites W161143260 @default.
- W1567750872 cites W1806885944 @default.
- W1567750872 cites W1872712927 @default.
- W1567750872 cites W1964157134 @default.
- W1567750872 cites W1968907717 @default.
- W1567750872 cites W1969342647 @default.
- W1567750872 cites W1969405733 @default.
- W1567750872 cites W1969553284 @default.
- W1567750872 cites W1970139159 @default.
- W1567750872 cites W1970213932 @default.
- W1567750872 cites W1975615008 @default.
- W1567750872 cites W1982853447 @default.
- W1567750872 cites W1984759958 @default.
- W1567750872 cites W1984865812 @default.
- W1567750872 cites W1985165311 @default.
- W1567750872 cites W1986977142 @default.
- W1567750872 cites W1987006861 @default.
- W1567750872 cites W1987082843 @default.
- W1567750872 cites W1987340085 @default.
- W1567750872 cites W1987937341 @default.
- W1567750872 cites W1991008023 @default.
- W1567750872 cites W1992873952 @default.
- W1567750872 cites W1995616568 @default.
- W1567750872 cites W1996521940 @default.
- W1567750872 cites W1996537616 @default.
- W1567750872 cites W1999176023 @default.
- W1567750872 cites W2000170431 @default.
- W1567750872 cites W2000376389 @default.
- W1567750872 cites W2003695272 @default.
- W1567750872 cites W2003859883 @default.
- W1567750872 cites W2006509394 @default.
- W1567750872 cites W2014657344 @default.
- W1567750872 cites W2014843698 @default.
- W1567750872 cites W2014899206 @default.
- W1567750872 cites W2016984872 @default.
- W1567750872 cites W2017209924 @default.
- W1567750872 cites W2017394412 @default.
- W1567750872 cites W2018434227 @default.
- W1567750872 cites W2020983392 @default.
- W1567750872 cites W2021451870 @default.
- W1567750872 cites W2022647590 @default.
- W1567750872 cites W2025081899 @default.
- W1567750872 cites W2025224715 @default.
- W1567750872 cites W2027266132 @default.
- W1567750872 cites W2027633770 @default.
- W1567750872 cites W2028444662 @default.
- W1567750872 cites W2028669354 @default.
- W1567750872 cites W2030064994 @default.
- W1567750872 cites W2030565228 @default.
- W1567750872 cites W2033555492 @default.
- W1567750872 cites W2033728878 @default.
- W1567750872 cites W2034284159 @default.
- W1567750872 cites W2034385303 @default.
- W1567750872 cites W2036730547 @default.
- W1567750872 cites W2036988959 @default.
- W1567750872 cites W2037530508 @default.
- W1567750872 cites W2038126024 @default.
- W1567750872 cites W2038213581 @default.
- W1567750872 cites W2038709381 @default.
- W1567750872 cites W2038767318 @default.
- W1567750872 cites W2039132486 @default.
- W1567750872 cites W2039436096 @default.
- W1567750872 cites W2039680999 @default.
- W1567750872 cites W2041263276 @default.
- W1567750872 cites W2045274208 @default.
- W1567750872 cites W2045562838 @default.
- W1567750872 cites W2045900172 @default.
- W1567750872 cites W2047339233 @default.
- W1567750872 cites W2049953991 @default.
- W1567750872 cites W2050440433 @default.
- W1567750872 cites W2052135636 @default.
- W1567750872 cites W2053369836 @default.
- W1567750872 cites W2054764666 @default.
- W1567750872 cites W2057247925 @default.
- W1567750872 cites W2057711788 @default.
- W1567750872 cites W2057803993 @default.
- W1567750872 cites W2058843732 @default.
- W1567750872 cites W2059792132 @default.
- W1567750872 cites W2064599819 @default.
- W1567750872 cites W2068124454 @default.
- W1567750872 cites W2068758281 @default.
- W1567750872 cites W2070144391 @default.
- W1567750872 cites W2070193928 @default.
- W1567750872 cites W207023704 @default.
- W1567750872 cites W2076039998 @default.