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- W1567752489 abstract "A29 Purpose: The activation of the mTOR pathway is recognized to be implicated in tumorigenesis of various malignancies through activation of p70S6 kinase (p70S6K) and 4E-binding protein-1 (4EBP1) leading to promotion of cellular proliferation and transition of cell cycle. This study was conducted to elucidate the prognostic value of activated mTOR and its downstream signaling molecules in patients with epithelial ovarian cancer. Experimental design: Immunohistochemical analysis using antibodies against p-mTOR, p-p70S6K and p-4EBP1 was performed on paraffin-embedded surgical specimens of 103 patients with epithelial ovarian carcinoma who underwent surgery. Clinical data were obtained from the review of medical records. Results: Expression of p-mTOR, p-p70S6K, and p-4EBP1 were identified in 47.6%, 64.1%, and 85.4% of epithelial ovarian carcinoma. Expression of p-4EBP1 was significantly correlated with stage ( P = 0.021), histologic grade ( P = 0.011), and residual mass ( P = 0.002). In addition, p-4EBP1 expression was associated with a significantly shorter disease-free survival in univariate analysis ( P = 0.013). p-4EBP1 correlated with p-p70S6K (Pearson9s correlation coefficient = 0.415, P P > 0.05). Conclusions: This study suggests that p-4EBP1 evaluated by immunohistochemistry may be helpful in prognostic evaluation of ovarian cancer and that mTOR might play a minor role in the activation of 4EBP1. These findings should be considered in the clinical study about the molecular targeted therapy using inhibitors of mTOR pathway." @default.
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- W1567752489 date "2008-10-01" @default.
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- W1567752489 title "Clinical significance of the mTOR pathway in epithelial ovarian cancer" @default.
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