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- W1567754411 abstract "Nesprins are large multi-domain proteins that link the nuclear envelope to the cytoskeleton and nucleoskeleton. Here we show that nesprin-1 and nesprin-2 play important roles in regulating cell shape and migration in endothelial cells. Nesprin-1 or nesprin-2 depletion by RNAi increased endothelial cell spread area and the length of cellular protrusions, as well as stimulating stress fibre assembly which correlated with an increase in F-actin levels. Nuclear area was also increased by nesprin depletion, and localization of the inner nuclear membrane protein emerin to the nuclear envelope was reduced. Depletion of nesprin-1 or nesprin-2 reduced migration of endothelial cells into a cell-free area, and decreased loop formation in an in vitro angiogenesis assay. Taken together, our results indicate that nesprin-1 and nesprin-2 both regulate nuclear and cytoplasmic architecture, which we propose leads to their effects on endothelial cell migration and angiogenic loop formation." @default.
- W1567754411 created "2016-06-24" @default.
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- W1567754411 date "2014-06-25" @default.
- W1567754411 modified "2023-10-06" @default.
- W1567754411 title "Nesprin-1 and nesprin-2 regulate endothelial cell shape and migration" @default.
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- W1567754411 doi "https://doi.org/10.1002/cm.21182" @default.
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