Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567759059> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W1567759059 endingPage "58.14" @default.
- W1567759059 startingPage "58.14" @default.
- W1567759059 abstract "Abstract Despite the many advances in personal genome analysis, the immunoglobulin repertoire of the genome, while central to human health, is in practice extraordinarily challenging to measure and analyze. There are several reasons for this, including the facts that each B cell contains a distinct antibody sequence encoded in its genome, that the antibody repertoire is not constant but changes over time, and the high similarity between antibody sequences. We have addressed this challenge by using high-throughput long read sequencing to perform immunogenetic characterization of expressed human antibody repertoires. Informatic analysis of large numbers of antibody heavy chain sequences from individual subjects allowed us to perform global characterizations of isotype distributions, clonal lineage structure of the repertoire and age-related mutational activity. With influenza vaccination as a specific stimulus, we used lineage analysis to measure the clonal structure and mutational distribution of individuals’ repertoires; analysis of this data showed that elderly subjects have a decreased number of lineages but an increased pre-vaccination mutation load in their repertoire and that some of these subjects have an oligoclonal character to their repertoire in which the diversity of the lineages is greatly reduced relative to younger subjects. These analyses may ultimately be useful as metrics to measure vaccine response and to further understand impaired immune function in aging." @default.
- W1567759059 created "2016-06-24" @default.
- W1567759059 creator A5009844754 @default.
- W1567759059 creator A5013153304 @default.
- W1567759059 creator A5022097783 @default.
- W1567759059 creator A5022840753 @default.
- W1567759059 creator A5025539602 @default.
- W1567759059 creator A5026022017 @default.
- W1567759059 creator A5032633979 @default.
- W1567759059 creator A5055293697 @default.
- W1567759059 creator A5066288600 @default.
- W1567759059 creator A5076713764 @default.
- W1567759059 creator A5087300910 @default.
- W1567759059 creator A5090505297 @default.
- W1567759059 date "2012-05-01" @default.
- W1567759059 modified "2023-09-26" @default.
- W1567759059 title "High Throughput Sequencing of the Human Antibody Repertoire in Response to Influenza Vaccination (58.14)" @default.
- W1567759059 doi "https://doi.org/10.4049/jimmunol.188.supp.58.14" @default.
- W1567759059 hasPublicationYear "2012" @default.
- W1567759059 type Work @default.
- W1567759059 sameAs 1567759059 @default.
- W1567759059 citedByCount "1" @default.
- W1567759059 countsByYear W15677590592016 @default.
- W1567759059 crossrefType "journal-article" @default.
- W1567759059 hasAuthorship W1567759059A5009844754 @default.
- W1567759059 hasAuthorship W1567759059A5013153304 @default.
- W1567759059 hasAuthorship W1567759059A5022097783 @default.
- W1567759059 hasAuthorship W1567759059A5022840753 @default.
- W1567759059 hasAuthorship W1567759059A5025539602 @default.
- W1567759059 hasAuthorship W1567759059A5026022017 @default.
- W1567759059 hasAuthorship W1567759059A5032633979 @default.
- W1567759059 hasAuthorship W1567759059A5055293697 @default.
- W1567759059 hasAuthorship W1567759059A5066288600 @default.
- W1567759059 hasAuthorship W1567759059A5076713764 @default.
- W1567759059 hasAuthorship W1567759059A5087300910 @default.
- W1567759059 hasAuthorship W1567759059A5090505297 @default.
- W1567759059 hasConcept C104317684 @default.
- W1567759059 hasConcept C121332964 @default.
- W1567759059 hasConcept C141231307 @default.
- W1567759059 hasConcept C159654299 @default.
- W1567759059 hasConcept C203014093 @default.
- W1567759059 hasConcept C22070199 @default.
- W1567759059 hasConcept C24890656 @default.
- W1567759059 hasConcept C2776817793 @default.
- W1567759059 hasConcept C2777991845 @default.
- W1567759059 hasConcept C2778473898 @default.
- W1567759059 hasConcept C2910693471 @default.
- W1567759059 hasConcept C51679486 @default.
- W1567759059 hasConcept C542903549 @default.
- W1567759059 hasConcept C54355233 @default.
- W1567759059 hasConcept C70721500 @default.
- W1567759059 hasConcept C78458016 @default.
- W1567759059 hasConcept C86803240 @default.
- W1567759059 hasConceptScore W1567759059C104317684 @default.
- W1567759059 hasConceptScore W1567759059C121332964 @default.
- W1567759059 hasConceptScore W1567759059C141231307 @default.
- W1567759059 hasConceptScore W1567759059C159654299 @default.
- W1567759059 hasConceptScore W1567759059C203014093 @default.
- W1567759059 hasConceptScore W1567759059C22070199 @default.
- W1567759059 hasConceptScore W1567759059C24890656 @default.
- W1567759059 hasConceptScore W1567759059C2776817793 @default.
- W1567759059 hasConceptScore W1567759059C2777991845 @default.
- W1567759059 hasConceptScore W1567759059C2778473898 @default.
- W1567759059 hasConceptScore W1567759059C2910693471 @default.
- W1567759059 hasConceptScore W1567759059C51679486 @default.
- W1567759059 hasConceptScore W1567759059C542903549 @default.
- W1567759059 hasConceptScore W1567759059C54355233 @default.
- W1567759059 hasConceptScore W1567759059C70721500 @default.
- W1567759059 hasConceptScore W1567759059C78458016 @default.
- W1567759059 hasConceptScore W1567759059C86803240 @default.
- W1567759059 hasIssue "1_Supplement" @default.
- W1567759059 hasLocation W15677590591 @default.
- W1567759059 hasOpenAccess W1567759059 @default.
- W1567759059 hasPrimaryLocation W15677590591 @default.
- W1567759059 hasRelatedWork W2061004617 @default.
- W1567759059 hasRelatedWork W2069184423 @default.
- W1567759059 hasRelatedWork W2131211314 @default.
- W1567759059 hasRelatedWork W2160578795 @default.
- W1567759059 hasRelatedWork W2911764498 @default.
- W1567759059 hasRelatedWork W2924247059 @default.
- W1567759059 hasRelatedWork W3088126680 @default.
- W1567759059 hasRelatedWork W4229549692 @default.
- W1567759059 hasRelatedWork W4300904202 @default.
- W1567759059 hasRelatedWork W2187207551 @default.
- W1567759059 hasVolume "188" @default.
- W1567759059 isParatext "false" @default.
- W1567759059 isRetracted "false" @default.
- W1567759059 magId "1567759059" @default.
- W1567759059 workType "article" @default.