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• W1567762579 abstract "BACKGROUND: Antibodies against polymorphic structures on human neutrophil antigens (HNAs) play a role in alloimmune‐mediated neutropenia and are the leading cause of antibody‐mediated transfusion‐related acute lung injury (TRALI). This study aimed to determine the frequencies of HNAs in the major Han ethnic group living in Guangdong Province, Southern China. STUDY DESIGN AND METHODS: A total of 493 healthy Chinese Han blood donors from Guangzhou were recruited. DNA samples were isolated and typed for all five HNA‐1, ‐2, ‐3, ‐4, and ‐5 systems using allele‐specific polymerase chain reaction approaches. Results were compared with available data from other Chinese cohorts and other Asian and Caucasian populations. RESULTS: In this cohort, the gene frequency for HNA‐1a (0.667) was approximately twice that of HNA‐1b (0.333). In contrast to Caucasian populations, HNA‐1a represents the most frequent allele in the Chinese population. HNA‐3 system genotyping revealed comparable frequencies for HNA‐3a (0.738) and ‐3b (0.262) in Chinese and Caucasian populations. Homozygous HNA‐3bb individuals were found in 5.64% of our cohort. HNA‐4 genotyping revealed no HNA‐4bb homozygous individuals. In contrast, HNA‐5bb homozygous individuals represented 2.43% of the population. Typing the HNA‐2 system for the single‐nucleotide polymorphism C42G showed that the C‐allele (69%) is overrepresented and is associated with an increased number of HNA‐2a–positive neutrophil subpopulations. CONCLUSION: This study describes for the first time the frequencies of all HNA systems, including the newly identified HNA‐3, within one cohort of Chinese Han population. Comparison with Caucasian populations may allow assessment of anti‐HNA alloimmunization and estimation of alloimmune neutropenia and TRALI incidence in Chinese populations." @default.
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• W1567762579 date "2010-12-16" @default.
• W1567762579 modified "2023-10-16" @default.
• W1567762579 title "The frequencies of human neutrophil alloantigens in the Chinese Han population of Guangzhou" @default.
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• W1567762579 doi "https://doi.org/10.1111/j.1537-2995.2010.02979.x" @default.
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