FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567771404> ?p ?o ?g. }

• W1567771404 endingPage "593" @default.
• W1567771404 startingPage "574" @default.
• W1567771404 abstract "Defective genomes present in serially passaged virus stocks derived from the ts LB2 mutant of herpes simplex virus type 1 were found to consist of repeat units in which sequences from the U L region, within map coordinates 0.356 and 0.429 of standard herpes simplex virus DNA, were covalently linked to sequences from the end of the S component. The major defective genome species consisted of repeat units which were 4.9 × 10 6 in molecular weight and contained a specific deletion within the U L segment. These ts LB2 defective genomes were stable through more than 35 sequential virus passages. The ratios of defective virus genomes to helper virus genomes present in different passages fluctuated in synchrony with the capacity of the passages to interfere with standard virus replication. Cells infected with passages enriched for defective genomes overproduced the infected cell polypeptide number 8, which had previously been mapped within the U L sequences present in the ts LB2 defective genomes. In contrast, the synthesis of most other infected cell polypeptides was delayed and reduced. The abundant synthesis of infected cell polypeptide number 8 followed the β regulatory pattern, as evident from kinetic studies and from experiments in which cycloheximide, canavanine, and phosphonoacetate were used. However, in contrast to many β (early) and γ (late) viral polypeptides, the synthesis of infected cell polypeptide number 8 was only minimally reduced when cells infected with serially passaged ts LB2 were incubated at 39°C. The ts LB2 mutation had previously been mapped within the domains of the gene encoding infected cell polypeptide number 4, the function of which was shown to be required for β and γ viral gene expression. It is thus possible that the ts LB2 mutation affects the synthesis of only a subset of the β and γ viral polypeptides. An additional polypeptide, 74.5 × 10 3 in molecular weight, was abundantly produced in cells infected with a number of ts LB2 passages. This polypeptide was most likely expressed from truncated gene templates within the most abundant, deleted repeats of ts LB2 defective virus DNA." @default.
• W1567771404 created "2016-06-24" @default.
• W1567771404 creator A5032540020 @default.
• W1567771404 creator A5070229619 @default.
• W1567771404 creator A5077221915 @default.
• W1567771404 date "1982-08-01" @default.
• W1567771404 modified "2023-09-23" @default.
• W1567771404 title "Structure and Expression of Class II Defective Herpes Simplex Virus Genomes Encoding Infected Cell Polypeptide Number 8" @default.
• W1567771404 cites W1478284728 @default.
• W1567771404 cites W1484493435 @default.
• W1567771404 cites W1493225362 @default.
• W1567771404 cites W1496779362 @default.
• W1567771404 cites W1505916481 @default.
• W1567771404 cites W1506521517 @default.
• W1567771404 cites W1510602789 @default.
• W1567771404 cites W1511493033 @default.
• W1567771404 cites W1511816912 @default.
• W1567771404 cites W1531399924 @default.
• W1567771404 cites W1544870259 @default.
• W1567771404 cites W1545728301 @default.
• W1567771404 cites W1552766729 @default.
• W1567771404 cites W1585915529 @default.
• W1567771404 cites W1645759506 @default.
• W1567771404 cites W1690553754 @default.
• W1567771404 cites W1772169244 @default.
• W1567771404 cites W1784877429 @default.
• W1567771404 cites W1793212752 @default.
• W1567771404 cites W1818519684 @default.
• W1567771404 cites W1820557301 @default.
• W1567771404 cites W1836251645 @default.
• W1567771404 cites W1891768184 @default.
• W1567771404 cites W1976494728 @default.
• W1567771404 cites W1978903086 @default.
• W1567771404 cites W1988482525 @default.
• W1567771404 cites W1988588500 @default.
• W1567771404 cites W1988886485 @default.
• W1567771404 cites W1991717074 @default.
• W1567771404 cites W1994730933 @default.
• W1567771404 cites W1995556647 @default.
• W1567771404 cites W2001339120 @default.
• W1567771404 cites W2001730972 @default.
• W1567771404 cites W2004747096 @default.
• W1567771404 cites W2017389379 @default.
• W1567771404 cites W2021530864 @default.
• W1567771404 cites W2023686279 @default.
• W1567771404 cites W2025617955 @default.
• W1567771404 cites W2027446542 @default.
• W1567771404 cites W2040441008 @default.
• W1567771404 cites W2058465077 @default.
• W1567771404 cites W2063450941 @default.
• W1567771404 cites W2064832858 @default.
• W1567771404 cites W2065796103 @default.
• W1567771404 cites W2066463674 @default.
• W1567771404 cites W2066709551 @default.
• W1567771404 cites W2069892944 @default.
• W1567771404 cites W2077587402 @default.
• W1567771404 cites W2081600660 @default.
• W1567771404 cites W2103724212 @default.
• W1567771404 cites W2119232680 @default.
• W1567771404 cites W2155168359 @default.
• W1567771404 cites W2165981749 @default.
• W1567771404 cites W2167414261 @default.
• W1567771404 doi "https://doi.org/10.1128/jvi.43.2.574-593.1982" @default.
• W1567771404 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/256161" @default.
• W1567771404 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6287032" @default.
• W1567771404 hasPublicationYear "1982" @default.
• W1567771404 type Work @default.
• W1567771404 sameAs 1567771404 @default.
• W1567771404 citedByCount "24" @default.
• W1567771404 countsByYear W15677714042012 @default.
• W1567771404 countsByYear W15677714042022 @default.
• W1567771404 crossrefType "journal-article" @default.
• W1567771404 hasAuthorship W1567771404A5032540020 @default.
• W1567771404 hasAuthorship W1567771404A5070229619 @default.
• W1567771404 hasAuthorship W1567771404A5077221915 @default.
• W1567771404 hasBestOaLocation W15677714041 @default.
• W1567771404 hasConcept C104317684 @default.
• W1567771404 hasConcept C132351222 @default.
• W1567771404 hasConcept C140704245 @default.
• W1567771404 hasConcept C141231307 @default.
• W1567771404 hasConcept C143065580 @default.
• W1567771404 hasConcept C144001008 @default.
• W1567771404 hasConcept C153911025 @default.
• W1567771404 hasConcept C159047783 @default.
• W1567771404 hasConcept C2522874641 @default.
• W1567771404 hasConcept C2781196997 @default.
• W1567771404 hasConcept C54355233 @default.
• W1567771404 hasConcept C86803240 @default.
• W1567771404 hasConceptScore W1567771404C104317684 @default.
• W1567771404 hasConceptScore W1567771404C132351222 @default.
• W1567771404 hasConceptScore W1567771404C140704245 @default.
• W1567771404 hasConceptScore W1567771404C141231307 @default.
• W1567771404 hasConceptScore W1567771404C143065580 @default.
• W1567771404 hasConceptScore W1567771404C144001008 @default.
• W1567771404 hasConceptScore W1567771404C153911025 @default.
• W1567771404 hasConceptScore W1567771404C159047783 @default.
• W1567771404 hasConceptScore W1567771404C2522874641 @default.
• W1567771404 hasConceptScore W1567771404C2781196997 @default.

• next