FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567778294> ?p ?o ?g. }

• W1567778294 endingPage "2670" @default.
• W1567778294 startingPage "2663" @default.
• W1567778294 abstract "Scorpion toxins that affect sodium channel (NaCh) gating in excitable cells are divided into alpha- and beta-classes. Whereas alpha-toxins have been found in scorpions throughout the world, anti-mammalian beta-toxins have been assigned, thus far, to 'New World' scorpions while anti-insect selective beta-toxins (depressant and excitatory) have been described only in the 'Old World'. This distribution suggested that diversification of beta-toxins into distinct pharmacological groups occurred after the separation of the continents, 150 million years ago. We have characterized a unique toxin, Lqhbeta1, from the 'Old World' scorpion, Leiurus quinquestriatus hebraeus, that resembles in sequence and activity both 'New World'beta-toxins as well as 'Old World' depressant toxins. Lqhbeta1 competes, with apparent high affinity, with anti-insect and anti-mammalian beta-toxins for binding to cockroach and rat brain synaptosomes, respectively. Surprisingly, Lqhbeta1 also competes with an anti-mammalian alpha-toxin on binding to rat brain NaChs. Analysis of Lqhbeta1 effects on rat brain and Drosophila Para NaChs expressed in Xenopus oocytes revealed a shift in the voltage-dependence of activation to more negative membrane potentials and a reduction in sodium peak currents in a manner typifying beta-toxin activity. Moreover, Lqhbeta1 resembles beta-toxins by having a weak effect on cardiac NaChs and a marked effect on rat brain and skeletal muscle NaChs. These multifaceted features suggest that Lqhbeta1 may represent an ancestral beta-toxin group in 'Old World' scorpions that gave rise, after the separation of the continents, to depressant toxins in 'Old World' scorpions and to various beta-toxin subgroups in 'New World' scorpions." @default.
• W1567778294 created "2016-06-24" @default.
• W1567778294 creator A5015381197 @default.
• W1567778294 creator A5018605114 @default.
• W1567778294 creator A5024891325 @default.
• W1567778294 creator A5037977891 @default.
• W1567778294 creator A5040138146 @default.
• W1567778294 creator A5053799789 @default.
• W1567778294 creator A5056255574 @default.
• W1567778294 creator A5060791253 @default.
• W1567778294 creator A5064858195 @default.
• W1567778294 creator A5069177326 @default.
• W1567778294 creator A5075107978 @default.
• W1567778294 creator A5083825554 @default.
• W1567778294 date "2003-06-01" @default.
• W1567778294 modified "2023-10-07" @default.
• W1567778294 title "An 'Old World' scorpion beta-toxin that recognizes both insect and mammalian sodium channels. A possible link towards diversification of beta-toxins" @default.
• W1567778294 cites W1542790713 @default.
• W1567778294 cites W1699466138 @default.
• W1567778294 cites W1758706501 @default.
• W1567778294 cites W1836738800 @default.
• W1567778294 cites W1965522673 @default.
• W1567778294 cites W1965672103 @default.
• W1567778294 cites W1966914157 @default.
• W1567778294 cites W1971605505 @default.
• W1567778294 cites W1983503942 @default.
• W1567778294 cites W1988333691 @default.
• W1567778294 cites W1991511662 @default.
• W1567778294 cites W1992670328 @default.
• W1567778294 cites W1994438398 @default.
• W1567778294 cites W2001807393 @default.
• W1567778294 cites W2006215578 @default.
• W1567778294 cites W2010228046 @default.
• W1567778294 cites W2011186542 @default.
• W1567778294 cites W2014395179 @default.
• W1567778294 cites W2016442704 @default.
• W1567778294 cites W2028922575 @default.
• W1567778294 cites W2031655743 @default.
• W1567778294 cites W2035565538 @default.
• W1567778294 cites W2037212965 @default.
• W1567778294 cites W2041350126 @default.
• W1567778294 cites W2041625664 @default.
• W1567778294 cites W2044387307 @default.
• W1567778294 cites W2052212640 @default.
• W1567778294 cites W2058630256 @default.
• W1567778294 cites W2076021040 @default.
• W1567778294 cites W2080641947 @default.
• W1567778294 cites W2084087308 @default.
• W1567778294 cites W2091661288 @default.
• W1567778294 cites W2094786998 @default.
• W1567778294 cites W2106970453 @default.
• W1567778294 cites W2128588563 @default.
• W1567778294 cites W2130865131 @default.
• W1567778294 cites W2138194706 @default.
• W1567778294 cites W2155190033 @default.
• W1567778294 cites W2157428118 @default.
• W1567778294 cites W2164377525 @default.
• W1567778294 cites W2170453572 @default.
• W1567778294 cites W4233657125 @default.
• W1567778294 doi "https://doi.org/10.1046/j.1432-1033.2003.03643.x" @default.
• W1567778294 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12787033" @default.
• W1567778294 hasPublicationYear "2003" @default.
• W1567778294 type Work @default.
• W1567778294 sameAs 1567778294 @default.
• W1567778294 citedByCount "57" @default.
• W1567778294 countsByYear W15677782942012 @default.
• W1567778294 countsByYear W15677782942013 @default.
• W1567778294 countsByYear W15677782942014 @default.
• W1567778294 countsByYear W15677782942015 @default.
• W1567778294 countsByYear W15677782942016 @default.
• W1567778294 countsByYear W15677782942017 @default.
• W1567778294 countsByYear W15677782942018 @default.
• W1567778294 countsByYear W15677782942021 @default.
• W1567778294 crossrefType "journal-article" @default.
• W1567778294 hasAuthorship W1567778294A5015381197 @default.
• W1567778294 hasAuthorship W1567778294A5018605114 @default.
• W1567778294 hasAuthorship W1567778294A5024891325 @default.
• W1567778294 hasAuthorship W1567778294A5037977891 @default.
• W1567778294 hasAuthorship W1567778294A5040138146 @default.
• W1567778294 hasAuthorship W1567778294A5053799789 @default.
• W1567778294 hasAuthorship W1567778294A5056255574 @default.
• W1567778294 hasAuthorship W1567778294A5060791253 @default.
• W1567778294 hasAuthorship W1567778294A5064858195 @default.
• W1567778294 hasAuthorship W1567778294A5069177326 @default.
• W1567778294 hasAuthorship W1567778294A5075107978 @default.
• W1567778294 hasAuthorship W1567778294A5083825554 @default.
• W1567778294 hasConcept C178790620 @default.
• W1567778294 hasConcept C185592680 @default.
• W1567778294 hasConcept C199360897 @default.
• W1567778294 hasConcept C2776174256 @default.
• W1567778294 hasConcept C2776676993 @default.
• W1567778294 hasConcept C2777367657 @default.
• W1567778294 hasConcept C2777612826 @default.
• W1567778294 hasConcept C2777884321 @default.
• W1567778294 hasConcept C2779448229 @default.
• W1567778294 hasConcept C2779608229 @default.
• W1567778294 hasConcept C2910159647 @default.
• W1567778294 hasConcept C41008148 @default.

• next