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• W1567781787 abstract "Abstract Reduced speed of cerebral information processing is a cognitive deficit associated with schizophrenia. Normal information processing speed (PS) requires intact white matter (WM) physiology to support information transfer. In a cohort of 107 subjects (47/60 patients/controls), we demonstrate that PS deficits in schizophrenia patients are explained by reduced WM integrity, which is measured using diffusion tensor imaging, mediated by the mismatch in WM/gray matter blood perfusion, and measured using arterial spin labeling. Our findings are specific to PS, and testing this hypothesis for patient‐control differences in working memory produces no explanation. We demonstrate that PS deficits in schizophrenia can be explained by neurophysiological alterations in cerebral WM. Whether the disproportionately low WM integrity in schizophrenia is due to illness or secondary due to this disorder deserves further examination. Hum Brain Mapp 36:3793–3804, 2015 . © 2015 Wiley Periodicals, Inc." @default.
• W1567781787 created "2016-06-24" @default.
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• W1567781787 date "2015-06-24" @default.
• W1567781787 modified "2023-09-22" @default.
• W1567781787 title "Perfusion shift from white to gray matter may account for processing speed deficits in schizophrenia" @default.
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• W1567781787 doi "https://doi.org/10.1002/hbm.22878" @default.
• W1567781787 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4714540" @default.
• W1567781787 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26108347" @default.
• W1567781787 hasPublicationYear "2015" @default.

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