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- W1567785877 abstract "Intrinsically disordered proteins (IDPs) have the potential to play a unique role in the study of proteins and the relationships between structure and function. Intrinsic affects chemical and cellular events such as cell signaling, macromolecular self-assembly, protein removal and crystal nucleation and growth. This chapter explores the structural principles by which IDPs act and reveals the prevalence of IDPs in the field of biomineralization. It has been demonstrated that proteins involved in biomineralization are frequently very extended and disordered. Moreover, the disordered structure is integral to how these proteins fulfill their functions. We have focused on the analysis of polypeptide folding, the role of posttranslational modifications, predictions of the structural and the degree of in secondary structures. Computational and biophysical strategies to analyze the secondary structures and evaluate the degree and nature of disorder in proteins are described. Biomineralization is the result of the orchestration of a series of protein-protein, proteinmineral and protein-cell interactions. Identifying unfolded functional domains in cell signaling may have a great impact in the study of tissue regeration and biomineral formation. IDPs are typically organic components of biominerals. It is believed that they could act as a regulatory coordinator for specific interactions of many proteins, and thus many physiological processes such as formation of dentin and bone, the formation of sea urchin and crusteacean exoskeletons. Here, we review what is currently understood about the molecular basis of biomineral formation. This includes protein interaction with metal ions, post-translational modifications, interactions with other proteins, or other factors that induce the formation of crystal shape and size along with the proper polymorph selection in relation to the role of IDPs." @default.
- W1567785877 created "2016-06-24" @default.
- W1567785877 creator A5019847887 @default.
- W1567785877 creator A5057058114 @default.
- W1567785877 creator A5078125259 @default.
- W1567785877 date "2012-02-17" @default.
- W1567785877 modified "2023-10-04" @default.
- W1567785877 title "Intrinsically Disordered Proteins in Biomineralization" @default.
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