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• W1567785955 abstract "Aim . To investigate the correlation between PPP1R12A gene copy number and clinical outcomes of oxaliplatin-based regimen in stage III colorectal cancer (CRC). Methods . A total of 139 paraffin-embedded tissue samples of stage III CRC patients who received oxaliplatin-based treatment after radical surgery were recruited. Genomic DNA was extracted and purified from paraffin-embedded sections. Quantitative PCR methods were used to detect the relative copy number (RCN) of PPP1R12A. Results . Statistical analysis demonstrated that low PPP1R12A RCN was associated with poor RFS (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mtext>HR</mml:mtext><mml:mo>=</mml:mo><mml:mn>2.186</mml:mn></mml:math>, 95% CI: 1.293–3.696;<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.003</mml:mn></mml:math>) and OS (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mtext>HR</mml:mtext><mml:mo>=</mml:mo><mml:mn>2.782</mml:mn></mml:math>, 95% CI: 1.531–5.052;<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.001</mml:mn></mml:math>). Additionally, when patients were stratified according to subgroups of stage III and tumor location, poor RFS and OS were also observed in the low PPP1R12A RCN group with significance (RFS: IIIB<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mtext>HR</mml:mtext><mml:mo>=</mml:mo><mml:mn>2.870</mml:mn></mml:math>,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.001</mml:mn></mml:math>; colon<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M7><mml:mtext>HR</mml:mtext><mml:mo>=</mml:mo><mml:mn>1.910</mml:mn></mml:math>,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M8><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.037</mml:mn></mml:math>; OS: IIIB<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M9><mml:mtext>HR</mml:mtext><mml:mo>=</mml:mo><mml:mn>3.527</mml:mn></mml:math>,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M10><mml:mi>P</mml:mi><mml:mo><</mml:mo><mml:mn>0.001</mml:mn></mml:math>; IIIC<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M11><mml:mtext>HR</mml:mtext><mml:mo>=</mml:mo><mml:mn>2.662</mml:mn></mml:math>,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M12><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.049</mml:mn></mml:math>; rectum<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M13><mml:mtext>HR</mml:mtext><mml:mo>=</mml:mo><mml:mn>4.229</mml:mn></mml:math>,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M14><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.002</mml:mn></mml:math>). Conclusion . Our findings suggest the copy number of PPP1R12A can independently predict recurrence and overall survival of stage III colorectal cancer patients receiving oxaliplatin-based chemotherapy." @default.
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• W1567785955 date "2015-01-01" @default.
• W1567785955 modified "2023-10-16" @default.
• W1567785955 title "PPP1R12A Copy Number Is Associated with Clinical Outcomes of Stage III CRC Receiving Oxaliplatin-Based Chemotherapy" @default.
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• W1567785955 doi "https://doi.org/10.1155/2015/417184" @default.
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