Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567852416> ?p ?o ?g. }
- W1567852416 abstract "AbstractMetformin has been extensively used in the management of type 2 diabetes mellitus (T2DM). A number of properties combined, including cost effectiveness, safety, weight neutrality, low risk of Hypoglycemia and cardiovascular protection moved metformin to the forefront of diabetes management and is now accepted as the standard first line therapy. Although other classes of glucose lowering medications were introduced to clinical practice in the recent times, none of such therapies has as yet demonstrated superiority to metformin to justify being considered as a first line therapeutic option. The use of metformin has extended in the last 2 decades to include diabetes prevention, gestational diabetes mellitus and polycystic ovary syndrome. There is accumulating evidence from observational studies to suggest a possible role for metformin in cancer prevention and in the management of non-alcoholic fatty liver disease. We reviewed the role of metformin in the prevention and treatment of T2DM and allied metabolic disorders and examined the non-glycaemic effects of metformin. In addition, we reviewed safety aspects pertinent to the usage of metformin in special clinical settings. Keywords: Metformin, type 2 diabetes, insulin resistance, cardiovascular protection, cancer, gastrointestinal intolerability, lactic acidosis" @default.
- W1567852416 created "2016-06-24" @default.
- W1567852416 creator A5000547596 @default.
- W1567852416 creator A5006004566 @default.
- W1567852416 creator A5031184455 @default.
- W1567852416 creator A5091539874 @default.
- W1567852416 date "2013-01-01" @default.
- W1567852416 modified "2023-10-15" @default.
- W1567852416 title "Emerging concepts in metformin therapy: Hyperglycaemia and beyond" @default.
- W1567852416 cites W1511593276 @default.
- W1567852416 cites W1526927233 @default.
- W1567852416 cites W172609984 @default.
- W1567852416 cites W1820234801 @default.
- W1567852416 cites W1861925105 @default.
- W1567852416 cites W1963764475 @default.
- W1567852416 cites W1970791113 @default.
- W1567852416 cites W1976269827 @default.
- W1567852416 cites W1977022592 @default.
- W1567852416 cites W1977985050 @default.
- W1567852416 cites W1978128204 @default.
- W1567852416 cites W1979161177 @default.
- W1567852416 cites W1979351664 @default.
- W1567852416 cites W1989689562 @default.
- W1567852416 cites W1992355896 @default.
- W1567852416 cites W1996641308 @default.
- W1567852416 cites W1997137520 @default.
- W1567852416 cites W1997683054 @default.
- W1567852416 cites W1999822521 @default.
- W1567852416 cites W2003621575 @default.
- W1567852416 cites W2007813402 @default.
- W1567852416 cites W2010801966 @default.
- W1567852416 cites W2013636620 @default.
- W1567852416 cites W2015808499 @default.
- W1567852416 cites W2016565181 @default.
- W1567852416 cites W2016974374 @default.
- W1567852416 cites W2021450389 @default.
- W1567852416 cites W2026967508 @default.
- W1567852416 cites W2027744617 @default.
- W1567852416 cites W2027804378 @default.
- W1567852416 cites W2028179750 @default.
- W1567852416 cites W2028533363 @default.
- W1567852416 cites W2035810031 @default.
- W1567852416 cites W2036555858 @default.
- W1567852416 cites W2039800528 @default.
- W1567852416 cites W2040109162 @default.
- W1567852416 cites W2041166009 @default.
- W1567852416 cites W2041244642 @default.
- W1567852416 cites W2042129134 @default.
- W1567852416 cites W2043807347 @default.
- W1567852416 cites W2046422668 @default.
- W1567852416 cites W2047377453 @default.
- W1567852416 cites W2049022861 @default.
- W1567852416 cites W2052580002 @default.
- W1567852416 cites W2055682358 @default.
- W1567852416 cites W2058725063 @default.
- W1567852416 cites W2058824697 @default.
- W1567852416 cites W2059158127 @default.
- W1567852416 cites W2059196301 @default.
- W1567852416 cites W2059526179 @default.
- W1567852416 cites W2060963949 @default.
- W1567852416 cites W2064018079 @default.
- W1567852416 cites W2070657377 @default.
- W1567852416 cites W2082325415 @default.
- W1567852416 cites W2094065060 @default.
- W1567852416 cites W2094156327 @default.
- W1567852416 cites W2095682936 @default.
- W1567852416 cites W2096315962 @default.
- W1567852416 cites W2100093159 @default.
- W1567852416 cites W2102307174 @default.
- W1567852416 cites W2104195235 @default.
- W1567852416 cites W2107166617 @default.
- W1567852416 cites W2107572009 @default.
- W1567852416 cites W2110651221 @default.
- W1567852416 cites W2111876001 @default.
- W1567852416 cites W2116059552 @default.
- W1567852416 cites W2117057656 @default.
- W1567852416 cites W2117559317 @default.
- W1567852416 cites W2119890307 @default.
- W1567852416 cites W2121225884 @default.
- W1567852416 cites W2122090242 @default.
- W1567852416 cites W2125613121 @default.
- W1567852416 cites W2126919962 @default.
- W1567852416 cites W2130780020 @default.
- W1567852416 cites W2131520853 @default.
- W1567852416 cites W2133632105 @default.
- W1567852416 cites W2134431421 @default.
- W1567852416 cites W2139523820 @default.
- W1567852416 cites W2140174229 @default.
- W1567852416 cites W2140846258 @default.
- W1567852416 cites W2146712490 @default.
- W1567852416 cites W2146883482 @default.
- W1567852416 cites W2149818749 @default.
- W1567852416 cites W2149842750 @default.
- W1567852416 cites W2154355204 @default.
- W1567852416 cites W2154719797 @default.
- W1567852416 cites W2155165300 @default.
- W1567852416 cites W2155942006 @default.
- W1567852416 cites W2157677292 @default.
- W1567852416 cites W2158666727 @default.
- W1567852416 cites W2158822657 @default.