FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567871149> ?p ?o ?g. }

• W1567871149 endingPage "1548" @default.
• W1567871149 startingPage "1540" @default.
• W1567871149 abstract "Abstract Acute myelofibrosis is often associated with acute megakaryoblastic leukemia (AMKBL). Although the exact mechanism for the progression of myelofibrosis in AMKBL is unclear, certain humoral factors from megakaryoblastic cells, the precursors of platelets, may be involved in the enhancement of collagen synthesis by bone marrow fibroblasts. The present study, therefore, is an investigation of the possible pathogenic role of transforming growth factor-beta (TGF-beta), known to be a very potent collagen-stimulating factor found in platelets in the myelofibrosis of AMKBL. The results obtained were as follows: (1) Conditioned media from peripheral megakaryoblasts taken from an AMKBL patient and from established megakaryoblast cell lines (MEG-01) had much greater stimulatory effects on collagen synthesis in bone marrow fibroblasts than conditioned media from other leukemic cell types. (2) Based on an assessment of soft agar colony formation, there was greater TGF-beta activity in media that had been conditioned from megakaryoblasts than in media from other leukemic cell types. (3) When compared with other leukemic-cell types, megakaryoblasts showed substantially greater expression of TGF-beta mRNA that was hybridized at 2.5 kb with a TGF-beta cDNA probe, and TGF-beta polypeptides were detected at 13 Kd with anti-TGF-beta antibodies. (4) The addition of the anti-TGF-beta antibody inhibited the stimulatory effects of the megakaryoblast conditioned medium on collagen synthesis in bone marrow fibroblasts. These results clearly suggest that megakaryoblasts produce and secrete an active form of TGF-beta and stimulate collagen synthesis in bone marrow fibroblasts in a paracrine manner." @default.
• W1567871149 created "2016-06-24" @default.
• W1567871149 creator A5000591714 @default.
• W1567871149 creator A5000608555 @default.
• W1567871149 creator A5008846610 @default.
• W1567871149 creator A5015509689 @default.
• W1567871149 creator A5037404066 @default.
• W1567871149 creator A5050087202 @default.
• W1567871149 creator A5055578080 @default.
• W1567871149 creator A5059047146 @default.
• W1567871149 creator A5067479935 @default.
• W1567871149 creator A5069703142 @default.
• W1567871149 date "1990-04-01" @default.
• W1567871149 modified "2023-09-26" @default.
• W1567871149 title "The production of transforming growth factor-beta in acute megakaryoblastic leukemia and its possible implications in myelofibrosis" @default.
• W1567871149 cites W110124829 @default.
• W1567871149 cites W1487452983 @default.
• W1567871149 cites W1501103780 @default.
• W1567871149 cites W1524114372 @default.
• W1567871149 cites W1538650273 @default.
• W1567871149 cites W1555643365 @default.
• W1567871149 cites W1577832196 @default.
• W1567871149 cites W1600868878 @default.
• W1567871149 cites W1627068912 @default.
• W1567871149 cites W1969241340 @default.
• W1567871149 cites W1979877257 @default.
• W1567871149 cites W2023545022 @default.
• W1567871149 cites W2032949589 @default.
• W1567871149 cites W2053418558 @default.
• W1567871149 cites W2053487253 @default.
• W1567871149 cites W2060333964 @default.
• W1567871149 cites W2062510144 @default.
• W1567871149 cites W2066160869 @default.
• W1567871149 cites W2073865988 @default.
• W1567871149 cites W2077077811 @default.
• W1567871149 cites W2086007941 @default.
• W1567871149 cites W2101108802 @default.
• W1567871149 cites W2130728614 @default.
• W1567871149 cites W2150113701 @default.
• W1567871149 cites W2168476587 @default.
• W1567871149 cites W218257244 @default.
• W1567871149 cites W2295333156 @default.
• W1567871149 cites W2320556745 @default.
• W1567871149 cites W258376682 @default.
• W1567871149 cites W369513917 @default.
• W1567871149 doi "https://doi.org/10.1182/blood.v75.7.1540.1540" @default.
• W1567871149 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2317561" @default.
• W1567871149 hasPublicationYear "1990" @default.
• W1567871149 type Work @default.
• W1567871149 sameAs 1567871149 @default.
• W1567871149 citedByCount "167" @default.
• W1567871149 countsByYear W15678711492012 @default.
• W1567871149 countsByYear W15678711492013 @default.
• W1567871149 countsByYear W15678711492014 @default.
• W1567871149 countsByYear W15678711492015 @default.
• W1567871149 countsByYear W15678711492016 @default.
• W1567871149 countsByYear W15678711492017 @default.
• W1567871149 countsByYear W15678711492018 @default.
• W1567871149 countsByYear W15678711492019 @default.
• W1567871149 countsByYear W15678711492020 @default.
• W1567871149 countsByYear W15678711492021 @default.
• W1567871149 countsByYear W15678711492022 @default.
• W1567871149 countsByYear W15678711492023 @default.
• W1567871149 crossrefType "journal-article" @default.
• W1567871149 hasAuthorship W1567871149A5000591714 @default.
• W1567871149 hasAuthorship W1567871149A5000608555 @default.
• W1567871149 hasAuthorship W1567871149A5008846610 @default.
• W1567871149 hasAuthorship W1567871149A5015509689 @default.
• W1567871149 hasAuthorship W1567871149A5037404066 @default.
• W1567871149 hasAuthorship W1567871149A5050087202 @default.
• W1567871149 hasAuthorship W1567871149A5055578080 @default.
• W1567871149 hasAuthorship W1567871149A5059047146 @default.
• W1567871149 hasAuthorship W1567871149A5067479935 @default.
• W1567871149 hasAuthorship W1567871149A5069703142 @default.
• W1567871149 hasBestOaLocation W15678711491 @default.
• W1567871149 hasConcept C118131993 @default.
• W1567871149 hasConcept C134018914 @default.
• W1567871149 hasConcept C153911025 @default.
• W1567871149 hasConcept C199360897 @default.
• W1567871149 hasConcept C203014093 @default.
• W1567871149 hasConcept C2776174256 @default.
• W1567871149 hasConcept C2778229498 @default.
• W1567871149 hasConcept C2778378607 @default.
• W1567871149 hasConcept C2778461978 @default.
• W1567871149 hasConcept C2780007613 @default.
• W1567871149 hasConcept C2780076729 @default.
• W1567871149 hasConcept C41008148 @default.
• W1567871149 hasConcept C502942594 @default.
• W1567871149 hasConcept C54355233 @default.
• W1567871149 hasConcept C81885089 @default.
• W1567871149 hasConcept C86803240 @default.
• W1567871149 hasConceptScore W1567871149C118131993 @default.
• W1567871149 hasConceptScore W1567871149C134018914 @default.
• W1567871149 hasConceptScore W1567871149C153911025 @default.
• W1567871149 hasConceptScore W1567871149C199360897 @default.
• W1567871149 hasConceptScore W1567871149C203014093 @default.
• W1567871149 hasConceptScore W1567871149C2776174256 @default.
• W1567871149 hasConceptScore W1567871149C2778229498 @default.

• next