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- W1567876629 abstract "The small Ras-like GTPase Ran/Gsp1p is a highly conserved nuclear protein required for the nucleocytoplasmic trafficking of macromolecules. Recent findings suggest that the Ran/Gsp1p pathway may have additional roles in several aspects of nuclear structure and function, including spindle assembly, nuclear envelope formation, nuclear pore complex assembly and RNA processing. Here, we provide evidence that Gsp1p can regulate telomeric function in Saccharomyces cerevisiae. We show that overexpression of PRP20, encoding the Gsp1p GDP/GTP nuclear exchange factor, specifically weakens telomeric silencing without detectably affecting nucleocytoplasmic transport. In addition to this silencing defect, we show that Rap1p and Sir3p delocalize from their normal telomeric foci. Interestingly, Gsp1p was found to interact genetically and physically with the telomeric component Sir4p. Taken together, these results suggest that the GSP1 pathway could regulate proper telomeric function in yeast through Sir4p." @default.
- W1567876629 created "2016-06-24" @default.
- W1567876629 creator A5006331835 @default.
- W1567876629 creator A5019156822 @default.
- W1567876629 creator A5026177547 @default.
- W1567876629 creator A5066649593 @default.
- W1567876629 date "2006-08-31" @default.
- W1567876629 modified "2023-10-02" @default.
- W1567876629 title "The nuclear GTPase Gsp1p can affect proper telomeric function through the Sir4 protein inSaccharomyces cerevisiae" @default.
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- W1567876629 doi "https://doi.org/10.1111/j.1365-2958.2006.05374.x" @default.
- W1567876629 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16956377" @default.
- W1567876629 hasPublicationYear "2006" @default.