Matches in SemOpenAlex for { <https://semopenalex.org/work/W1567876634> ?p ?o ?g. }
- W1567876634 endingPage "68" @default.
- W1567876634 startingPage "59" @default.
- W1567876634 abstract "Gain-of-function mutations of kit tyrosine kinase receptor are associated with mastocytosis. Two subclones of the HMC1 mast leukaemia cell line were used; both express an identical KIT allele-specific regulatory type mutation (V560G), but differ in that one also expresses an enzymatic site type mutation (D816V) that confers on them resistance to imatinib mesylate tyrosine kinase inhibitor. In both cell lines, proliferation was suppressed and apoptosis induced by the combination of KIT gene silencing and α-tocopherol succinate (α-TOS), a derivate of α-tocopherol, also known as vitamin E. Furthermore, HMC1 cells with decreased kit levels by KIT silencing, failed to form tumours when xenotransplanted into immunocompromised mice and the animals were treated systemically with α-TOS. Targeting kit in the presence of α-TOS represents a new approach against proliferation of human mast leukaemia cell lines." @default.
- W1567876634 created "2016-06-24" @default.
- W1567876634 creator A5061698320 @default.
- W1567876634 creator A5064237990 @default.
- W1567876634 creator A5083143206 @default.
- W1567876634 date "2010-01-01" @default.
- W1567876634 modified "2023-09-26" @default.
- W1567876634 title "Combination of KIT gene silencing and tocopherol succinate may offer improved therapeutic approaches for human mastocytosis" @default.
- W1567876634 cites W1593609690 @default.
- W1567876634 cites W1967361316 @default.
- W1567876634 cites W1975240950 @default.
- W1567876634 cites W1975727111 @default.
- W1567876634 cites W1976060898 @default.
- W1567876634 cites W1978030866 @default.
- W1567876634 cites W1979837223 @default.
- W1567876634 cites W1986585141 @default.
- W1567876634 cites W1986925699 @default.
- W1567876634 cites W1986936995 @default.
- W1567876634 cites W1988821060 @default.
- W1567876634 cites W1993327121 @default.
- W1567876634 cites W1996624412 @default.
- W1567876634 cites W1999653639 @default.
- W1567876634 cites W2016518678 @default.
- W1567876634 cites W2017991840 @default.
- W1567876634 cites W2018203820 @default.
- W1567876634 cites W2029541049 @default.
- W1567876634 cites W2034715465 @default.
- W1567876634 cites W2041415161 @default.
- W1567876634 cites W2044518419 @default.
- W1567876634 cites W2046639009 @default.
- W1567876634 cites W2053314612 @default.
- W1567876634 cites W2055349083 @default.
- W1567876634 cites W2056461868 @default.
- W1567876634 cites W2066233960 @default.
- W1567876634 cites W2066824732 @default.
- W1567876634 cites W2073284449 @default.
- W1567876634 cites W2102598497 @default.
- W1567876634 cites W2109331088 @default.
- W1567876634 cites W2110577324 @default.
- W1567876634 cites W2118240561 @default.
- W1567876634 cites W2121990442 @default.
- W1567876634 cites W2124127967 @default.
- W1567876634 cites W2153408446 @default.
- W1567876634 cites W2157748890 @default.
- W1567876634 cites W2162525969 @default.
- W1567876634 cites W2171109371 @default.
- W1567876634 cites W2171620774 @default.
- W1567876634 cites W4249393610 @default.
- W1567876634 doi "https://doi.org/10.1111/j.1365-2141.2009.07918.x" @default.
- W1567876634 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19804454" @default.
- W1567876634 hasPublicationYear "2010" @default.
- W1567876634 type Work @default.
- W1567876634 sameAs 1567876634 @default.
- W1567876634 citedByCount "3" @default.
- W1567876634 countsByYear W15678766342012 @default.
- W1567876634 countsByYear W15678766342016 @default.
- W1567876634 crossrefType "journal-article" @default.
- W1567876634 hasAuthorship W1567876634A5061698320 @default.
- W1567876634 hasAuthorship W1567876634A5064237990 @default.
- W1567876634 hasAuthorship W1567876634A5083143206 @default.
- W1567876634 hasConcept C101544691 @default.
- W1567876634 hasConcept C104317684 @default.
- W1567876634 hasConcept C109159458 @default.
- W1567876634 hasConcept C119056186 @default.
- W1567876634 hasConcept C153911025 @default.
- W1567876634 hasConcept C170493617 @default.
- W1567876634 hasConcept C184235292 @default.
- W1567876634 hasConcept C2022786 @default.
- W1567876634 hasConcept C203014093 @default.
- W1567876634 hasConcept C2777583451 @default.
- W1567876634 hasConcept C2778729363 @default.
- W1567876634 hasConcept C2779726688 @default.
- W1567876634 hasConcept C2780581156 @default.
- W1567876634 hasConcept C28328180 @default.
- W1567876634 hasConcept C2910840531 @default.
- W1567876634 hasConcept C3019892230 @default.
- W1567876634 hasConcept C42362537 @default.
- W1567876634 hasConcept C502942594 @default.
- W1567876634 hasConcept C54355233 @default.
- W1567876634 hasConcept C86803240 @default.
- W1567876634 hasConceptScore W1567876634C101544691 @default.
- W1567876634 hasConceptScore W1567876634C104317684 @default.
- W1567876634 hasConceptScore W1567876634C109159458 @default.
- W1567876634 hasConceptScore W1567876634C119056186 @default.
- W1567876634 hasConceptScore W1567876634C153911025 @default.
- W1567876634 hasConceptScore W1567876634C170493617 @default.
- W1567876634 hasConceptScore W1567876634C184235292 @default.
- W1567876634 hasConceptScore W1567876634C2022786 @default.
- W1567876634 hasConceptScore W1567876634C203014093 @default.
- W1567876634 hasConceptScore W1567876634C2777583451 @default.
- W1567876634 hasConceptScore W1567876634C2778729363 @default.
- W1567876634 hasConceptScore W1567876634C2779726688 @default.
- W1567876634 hasConceptScore W1567876634C2780581156 @default.
- W1567876634 hasConceptScore W1567876634C28328180 @default.
- W1567876634 hasConceptScore W1567876634C2910840531 @default.
- W1567876634 hasConceptScore W1567876634C3019892230 @default.
- W1567876634 hasConceptScore W1567876634C42362537 @default.
- W1567876634 hasConceptScore W1567876634C502942594 @default.